Document Detail

Contrasting effects of estradiol and progesterone on respiratory pattern and hypoxic ventilatory response in newborn male rats.
MedLine Citation:
PMID:  18760385     Owner:  NLM     Status:  MEDLINE    
We tested the hypothesis that postnatal exposure to progesterone or estradiol exerts distinct effects on respiratory control, apnea frequency, and on hypoxic ventilatory response (HVR). To this aim, we assessed breathing pattern using whole body plethysmography in normoxia and during a sustained hypoxic exposure (10% O(2)-30min) in 10-day-old male rats raised by dams implanted with osmotic minipumps delivering either estradiol (E(2), 7.0microgday(-1)), estradiol+progesterone (E(2)+P, 7.0+70microgday(-1)) or vehicle (propylene glycol) at a regular flow rate throughout postnatal days 1-14. Compared to vehicle, E(2) and E(2)+P pups had a reduced ventilation, metabolic rate and rectal temperature. HVR was specifically increased in E(2)+P pups compared to controls and E(2) pups. On the contrary, both E(2) and E(2)+P pups did not reduced metabolism as much as controls during hypoxic exposure, and the decrease in rectal temperature was abolished. Surprisingly, E(2)+P pups showed a dramatic elevation of sigh frequency, while progesterone (in E(2)+P compared to E(2) and Veh pups) reduced apnea frequency. These findings are relevant to better understand the role of placental steroids on respiratory and metabolic control during early development in rats, and could ultimately contribute to a better understanding of specific respiratory control disorders in preterm neonates, which are chronically deprived from placental steroids exposure.
Raluca Lefter; Van Diep Doan; Vincent Joseph
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-08-06
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  164     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-01     Completed Date:  2009-04-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  312-8     Citation Subset:  IM    
Department of Pediatrics, Laval University, Centre de Recherche (D0-711), Hôpital St-François d'Assise, 10 rue de l'Espinay, Quebec G1L 3L5, Canada.
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MeSH Terms
Analysis of Variance
Animals, Newborn
Anoxia / physiopathology*
Drug Delivery Systems
Estradiol / pharmacology*
Plethysmography, Whole Body / methods
Progesterone / pharmacology*
Pulmonary Ventilation / physiology
Rats, Sprague-Dawley
Respiration / drug effects*
Sex Characteristics
Reg. No./Substance:
50-28-2/Estradiol; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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