Document Detail


Contrasting effects of the competitive NMDA antagonist CPP and the non-competitive NMDA antagonist MK 801 on performance of an operant delayed matching to position task in rats.
MedLine Citation:
PMID:  7870988     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of the competitive NMDA antagonist CPP and the non-competitive NMDA antagonist MK 801 (dizolcipine) on short term working memory in the rat were investigated. The behavioural paradigm used was discrete trial, operant delayed matching to position, as originally described by Dunnett (1985), with delays of 0, 5, 15 and 30 s. These delays generated an orderly "forgetting" curve in control rats, with matching accuracy decreasing from approximately 100% at 0-s delay to approximately 75% at 30-s delay. Intraperitoneal (IP) administration of CPP (10 mg/kg) produced a marked delay dependent impairment in performance, suggesting a specific effect on short term working memory. This effect was accompanied by a minor decrease in the speed of responding, and a slight increase in the number of missed trials. Lower doses of CPP had no significant effects on either matching accuracy or sedation. In contrast, IP administration of MK 801 (0.1 and 0.2 mg/kg) caused a marked delay independent impairment in the accuracy of delayed matching performance, suggesting a non-specific disruption of performance. A lower dose (0.05 mg/kg) of MK 801 had no significant effect on matching accuracy. The two lower doses of MK 801 increased the number of nose pokes made during the delays and tended to increase the speed of responding, suggesting a stimulant-like action. The highest dose of MK 801 had the opposite effects and also decreased the number of trials completed.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
B J Cole; M Klewer; G H Jones; D N Stephens
Related Documents :
1315138 - Hyperactivity, hyper-reactivity, and sensorimotor deficits induced by low doses of the ...
23351338 - Oral green tea catechin metabolites are incorporated into human skin and protect agains...
7649958 - Do high doses of stimulants impair flexible thinking in attention-deficit hyperactivity...
22617018 - Lens crystallin response to whole body irradiation with single and fractionated doses o...
8359178 - The effect of different dosage schedules of cisapride on gastric emptying in idiopathic...
6889048 - Estrogen treatment of tall girls: risk of thrombosis?
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Psychopharmacology     Volume:  111     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  1993  
Date Detail:
Created Date:  1995-03-28     Completed Date:  1995-03-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  465-71     Citation Subset:  IM    
Affiliation:
Department of Neuropsychopharmacology, Schering AG, Berlin, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Conditioning, Operant / drug effects*
Discrimination (Psychology) / drug effects
Dizocilpine Maleate / pharmacology*
Dose-Response Relationship, Drug
Male
Memory, Short-Term / drug effects
Mental Recall / drug effects
Piperazines / pharmacology*
Rats
Rats, Wistar
Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors*
Chemical
Reg. No./Substance:
0/Piperazines; 0/Receptors, N-Methyl-D-Aspartate; 100828-16-8/3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid; 77086-22-7/Dizocilpine Maleate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Reduction of morphine dependence and potentiation of analgesia by chronic co-administration of nifed...
Next Document:  Effects of smoking on thermal pain threshold in deprived and minimally-deprived habitual smokers.