Document Detail

Contrasting effects of the competitive NMDA antagonist CPP and the non-competitive NMDA antagonist MK 801 on performance of an operant delayed matching to position task in rats.
MedLine Citation:
PMID:  7870988     Owner:  NLM     Status:  MEDLINE    
The effects of the competitive NMDA antagonist CPP and the non-competitive NMDA antagonist MK 801 (dizolcipine) on short term working memory in the rat were investigated. The behavioural paradigm used was discrete trial, operant delayed matching to position, as originally described by Dunnett (1985), with delays of 0, 5, 15 and 30 s. These delays generated an orderly "forgetting" curve in control rats, with matching accuracy decreasing from approximately 100% at 0-s delay to approximately 75% at 30-s delay. Intraperitoneal (IP) administration of CPP (10 mg/kg) produced a marked delay dependent impairment in performance, suggesting a specific effect on short term working memory. This effect was accompanied by a minor decrease in the speed of responding, and a slight increase in the number of missed trials. Lower doses of CPP had no significant effects on either matching accuracy or sedation. In contrast, IP administration of MK 801 (0.1 and 0.2 mg/kg) caused a marked delay independent impairment in the accuracy of delayed matching performance, suggesting a non-specific disruption of performance. A lower dose (0.05 mg/kg) of MK 801 had no significant effect on matching accuracy. The two lower doses of MK 801 increased the number of nose pokes made during the delays and tended to increase the speed of responding, suggesting a stimulant-like action. The highest dose of MK 801 had the opposite effects and also decreased the number of trials completed.(ABSTRACT TRUNCATED AT 250 WORDS)
B J Cole; M Klewer; G H Jones; D N Stephens
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Psychopharmacology     Volume:  111     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  1993  
Date Detail:
Created Date:  1995-03-28     Completed Date:  1995-03-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  465-71     Citation Subset:  IM    
Department of Neuropsychopharmacology, Schering AG, Berlin, Germany.
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MeSH Terms
Conditioning, Operant / drug effects*
Discrimination (Psychology) / drug effects
Dizocilpine Maleate / pharmacology*
Dose-Response Relationship, Drug
Memory, Short-Term / drug effects
Mental Recall / drug effects
Piperazines / pharmacology*
Rats, Wistar
Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors*
Reg. No./Substance:
0/Piperazines; 0/Receptors, N-Methyl-D-Aspartate; 100828-16-8/3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid; 77086-22-7/Dizocilpine Maleate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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