Document Detail

Contrasting effect on cardiac output of digoxin and gitoxin in humans during congestive heart failure.
MedLine Citation:
PMID:  7263109     Owner:  NLM     Status:  MEDLINE    
Recent studies have demonstrated that the biovailability of gitoxin could be increased to 100%. Favorable pharmacokinetic parameters for this glycoside have also been found in humans. The present paper deals with the comparative hemodynamic effect of digoxin and gitoxin on nine patients suffering from heart failure. The study was conducted in a coronary care unit with continuous hemodynamic monitoring. After intravenous administration of 1 mg digoxin or gitoxin, only gitoxin was observed to have an inotropic effect leading to significant improvement of the low cardiac output in these patients.
J Col; W Wijns; L Brasseur; M Lesne
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of clinical pharmacology, therapy, and toxicology     Volume:  19     ISSN:  0174-4879     ISO Abbreviation:  Int J Clin Pharmacol Ther Toxicol     Publication Date:  1981 Jul 
Date Detail:
Created Date:  1981-10-14     Completed Date:  1981-10-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8003415     Medline TA:  Int J Clin Pharmacol Ther Toxicol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  314-8     Citation Subset:  IM    
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MeSH Terms
Cardiac Glycosides / pharmacology*
Cardiac Output / drug effects*
Digoxin / pharmacology*
Heart Failure / physiopathology*
Hemodynamics / drug effects
Time Factors
Reg. No./Substance:
0/Cardiac Glycosides; 20830-75-5/Digoxin; 4562-36-1/gitoxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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