Document Detail


Contrasting effect on cardiac output of digoxin and gitoxin in humans during congestive heart failure.
MedLine Citation:
PMID:  7263109     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent studies have demonstrated that the biovailability of gitoxin could be increased to 100%. Favorable pharmacokinetic parameters for this glycoside have also been found in humans. The present paper deals with the comparative hemodynamic effect of digoxin and gitoxin on nine patients suffering from heart failure. The study was conducted in a coronary care unit with continuous hemodynamic monitoring. After intravenous administration of 1 mg digoxin or gitoxin, only gitoxin was observed to have an inotropic effect leading to significant improvement of the low cardiac output in these patients.
Authors:
J Col; W Wijns; L Brasseur; M Lesne
Related Documents :
9761439 - The effects of mechanical cardiac stabilization on left ventricular performance.
18703639 - Endocannabinoids and liver disease. v. endocannabinoids as mediators of vascular and ca...
7640119 - Continuous measurement of cardiac output during aortic cross-clamping by the oesophagea...
9181169 - Large increase in cardiac output in a patient with ards and acute right heart failure d...
7408149 - Perioperative echocardiographic evaluation of cardiovascular function: assessment of ch...
912739 - Atypical late cardiac tamponade after mitral valve replacement: case presentation with ...
570899 - The pathophysiology and diverse etiology of septal perforator compression.
17269879 - Cardiac evaluation of anesthetized grevy's zebras (equus grevyi).
9790379 - Altered apoptosis levels in hearts of human fetuses with down syndrome.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of clinical pharmacology, therapy, and toxicology     Volume:  19     ISSN:  0174-4879     ISO Abbreviation:  Int J Clin Pharmacol Ther Toxicol     Publication Date:  1981 Jul 
Date Detail:
Created Date:  1981-10-14     Completed Date:  1981-10-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8003415     Medline TA:  Int J Clin Pharmacol Ther Toxicol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  314-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Cardiac Glycosides / pharmacology*
Cardiac Output / drug effects*
Digoxin / pharmacology*
Female
Heart Failure / physiopathology*
Hemodynamics / drug effects
Humans
Male
Time Factors
Chemical
Reg. No./Substance:
0/Cardiac Glycosides; 20830-75-5/Digoxin; 4562-36-1/gitoxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Pharmacokinetics of etofylline after intravenous and oral administration to humans.
Next Document:  Pharmacokinetics of naproxen in patients with hypoproteinemia.