Document Detail


Contrasting clinical outcomes between different modes of peritoneal dialysis regimens: two center experiences in China.
MedLine Citation:
PMID:  18379549     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the present study, we compared the clinical outcomes between two different modes of peritoneal dialysis (PD) and explored the possible role of volume overload in continuous ambulatory peritoneal dialysis (CAPD) patients. A longitudinal and a cross-sectional study were included. Patients received either an 'adaptative ultrafiltration (UF)' PD regimen, which focused on gradually increasing peritoneal ultrafiltration (PDi group), or traditional PD treatment (PDt group). Patients' demographic characteristics, nutritional status, fluid removal as well as fluid status were recorded. In the cross-sectional study, all clinically stable patients who were treated with CAPD for at least three months were enrolled and grouped according to their time on dialysis: short term, medium term, and long term. Both studies showed that PDi and PDt patients had distinct fluid removal patterns. PDt patients had decreased total fluid removal with worsening fluid status and deteriorating nutritional status, whereas PDi patients remained rather stable in relation to fluid removal, fluid status, and improving nutritional status. Cox regression analysis confirmed that the PDi group had better patient survival than the PDt group. Our data suggest that traditional and 'adaptative UF' PD therapy may have distinct fluid removal patterns over time on dialysis, and this unique pattern might partly explain the still unacceptable high mortality of long-term CAPD patients.
Authors:
W Chen; Y Gu; Q-F Han; T Wang
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Kidney international. Supplement     Volume:  -     ISSN:  0098-6577     ISO Abbreviation:  Kidney Int. Suppl.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-01     Completed Date:  2008-05-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7508622     Medline TA:  Kidney Int Suppl     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S56-62     Citation Subset:  IM    
Affiliation:
Division of Nephrology, Peking University Third Hospital, Beijing, China.
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MeSH Terms
Descriptor/Qualifier:
Aged
China
Cohort Studies
Cross-Sectional Studies
Diabetes Mellitus / therapy*
Female
Glomerulonephritis / therapy*
Humans
Longitudinal Studies
Male
Middle Aged
Nephrosclerosis / therapy*
Nutritional Status
Peritoneal Dialysis / methods*
Peritoneal Dialysis, Continuous Ambulatory / methods*
Regression Analysis
Treatment Outcome
Ultrafiltration / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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