Document Detail

Contrasting effects of n-3 and n-6 fatty acids on cyclooxygenase-2 in model systems for arthritis.
MedLine Citation:
PMID:  19784684     Owner:  NLM     Status:  MEDLINE    
Cyclooxygenase-2 (COX-2) is intimately involved in symptoms of arthritis while dietary n-3 polyunsaturated fatty acids (PUFA) are thought to be beneficial. In these experiments, using both bovine and human in vitro systems that mimic features of arthritis, we show that the n-3 PUFA eicosapentaenoic acid (EPA) is able to reduce mRNA and protein levels of COX-2. Activity, as assessed through prostaglandin E(2) formation, was also reduced in a dose-dependent manner. These effects of EPA contrasted noticeably with the n-6 PUFA, arachidonic acid. The data provide direct evidence for a molecular mechanism by which dietary n-3 PUFA, such as EPA, can reduce inflammation and, hence, associated symptoms in arthritis.
Samantha Hurst; Sarah G Rees; Peter F Randerson; Bruce Caterson; John L Harwood
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-26
Journal Detail:
Title:  Lipids     Volume:  44     ISSN:  1558-9307     ISO Abbreviation:  Lipids     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2010-01-29     Completed Date:  2010-08-27     Revised Date:  2011-12-01    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  889-96     Citation Subset:  IM    
Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3AX, UK.
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MeSH Terms
Arthritis / diet therapy*,  enzymology*,  pathology
Cartilage, Articular / drug effects,  enzymology,  pathology
Cells, Cultured
Cyclooxygenase 2 / biosynthesis,  metabolism*
Cyclooxygenase 2 Inhibitors / pharmacology,  therapeutic use
Dietary Fats / pharmacology,  therapeutic use
Fatty Acids, Omega-3 / pharmacology*,  therapeutic use
Fatty Acids, Omega-6 / pharmacology*,  therapeutic use
Grant Support
D16961//Biotechnology and Biological Sciences Research Council; //Arthritis Research UK
Reg. No./Substance:
0/Cyclooxygenase 2 Inhibitors; 0/Dietary Fats; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; EC 2

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