Document Detail

Contrast ultrasound perfusion imaging of lower extremities in peripheral arterial disease: a novel diagnostic method.
MedLine Citation:
PMID:  16308326     Owner:  NLM     Status:  MEDLINE    
AIMS: The purpose of this study was to establish contrast-enhanced ultrasound perfusion imaging (CUPI) of the lower extremities as a novel non-invasive diagnostic tool for patients with peripheral arterial disease (PAD). METHODS AND RESULTS: Ultrasound contrast agent (SonoVue) was injected into a peripheral vein of 16 control subjects and 16 PAD patients and its appearance in the calf muscle was detected by low-energy harmonic ultrasound. Analysis of the wash-in curves revealed that PAD patients had a significantly longer time to peak intensity (TTP), i.e. duration of maximum contrast perfusion [37 s (19-79 s) in control subjects vs. 56 s (32-104 s) in PAD patients at rest, age-adjusted P=0.002]. Exercise stress test of the calf muscle resulted in a decrease of the TTP, maintaining the significant difference in TTP between the groups [19 s (8-37 s) in control subjects vs. 32 s (18-48 s) in PAD patients after exercise, age-adjusted P=0.004]. Neither ankle-brachial index and TTP nor age and TTP showed a significant correlation. CONCLUSION: CUPI reflects the regional blood circulation of the calf muscle. In this pilot study, PAD patients show a significantly longer TTP than control subjects. The clinical relevance of CUPI is topic of ongoing studies.
Daniel Duerschmied; Lisa Olson; Manfred Olschewski; Alexandra Rossknecht; Gabriele Freund; Christoph Bode; Christoph Hehrlein
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-11-24
Journal Detail:
Title:  European heart journal     Volume:  27     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-13     Completed Date:  2006-07-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  England    
Other Details:
Languages:  eng     Pagination:  310-5     Citation Subset:  IM    
Department of Cardiology and Angiology, University Hospital of Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany.
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MeSH Terms
Aged, 80 and over
Case-Control Studies
Contrast Media
Intermittent Claudication / physiopathology,  ultrasonography*
Leg / blood supply
Middle Aged
Peripheral Vascular Diseases / physiopathology,  ultrasonography*
Phospholipids / diagnostic use*
Pilot Projects
Sulfur Hexafluoride / diagnostic use*
Reg. No./Substance:
0/Contrast Media; 0/Phospholipids; 0/contrast agent BR1; 2551-62-4/Sulfur Hexafluoride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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