| Contrast timing in computed tomography: Effect of different contrast media concentrations on bolus geometry. | |
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MedLine Citation:
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PMID: 22297184 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To assess the effect of low-osmolar, monomeric contrast media with different iodine concentrations on bolus shape in aortic CT angiography. MATERIALS AND METHODS: Repeated sequential computed tomography scanning of the descending aorta of eight beagle dogs (5 male, 12.7±3.1kg) was performed without table movement with a standardized CT scan protocol. Iopromide 300 (300mgI/mL), iopromide 370 (370mgI/mL) and iomeprol 400 (400mgI/mL) were administered via a foreleg vein with an identical iodine delivery rate of 1.2gI/s and a total iodine dose of 300mgI/kg body weight. Time-enhancement curves were computed and analyzed. RESULTS: Iopromide 300 showed the highest peak enhancement (445.2±89.1 HU), steepest up-slope (104.2±17.5 HU/s) and smallest full width at half maximum (FWHM; 5.8±1.0s). Peak enhancement, duration of FWHM, enhancement at FWHM and up-slope differed significantly between iopromide 300 and iomeprol 400 (p<0.05). Except for enhancement at FWHM there were no significant differences between iopromide 300 and iopromide 370 and iopromide 370 and iomeprol 400 (p>0.05). CONCLUSIONS: Low viscous iopromide 300 results in a better defined bolus with a significantly higher peak enhancement, steeper up-slope and smaller FWHM when compared to iomeprol 400. These characteristics potentially affect contrast timing. |
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Authors:
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Andreas H Mahnken; Gregor Jost; Peter Seidensticker; Christiane Kuhl; Hubertus Pietsch |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-30 |
Journal Detail:
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Title: European journal of radiology Volume: - ISSN: 1872-7727 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-2-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106411 Medline TA: Eur J Radiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Diagnostic and Interventional Radiology, RWTH Aachen University, Germany; Applied Medical Engineering, Helmholtz Institute of Biomedical Engineering, RWTH Aachen University, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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