Document Detail

Contrast sensitivity and vernier acuity in amblyopic monkeys.
MedLine Citation:
PMID:  8273294     Owner:  NLM     Status:  MEDLINE    
Human psychophysical studies suggest that strabismic and anisometropic amblyopes may have characteristically different patterns of visual loss. In particular, anisometropic amblyopes often show deficits on spatial localization tasks that scale with their spatial resolution losses, whereas strabismic amblyopes can show localization deficits that are large relative to their losses in spatial resolution. We have compared the performance of non-human primates with experimentally-induced anisometropic and strabismic amblyopia on contrast detection and vernier acuity tasks. The performance of both groups of animals was fundamentally similar: both strabismic and anisometropic monkeys showed deficits in spatial localization that were large relative to their resolution losses, although the animals with the most disproportionate losses were strabismic. We investigated the extent to which contrast sensitivity losses accounted for the vernier acuity deficits. The results showed that, in most cases of either strabismic or anisometropic amblyopia, when the vernier stimuli for each eye were equated in terms of effective contrast, the extent of the vernier acuity deficit was reduced to approximately the extent of the spatial resolution deficit. In two cases, both of strabismic amblyopia, we found that equating the stimuli in this way was not sufficient to make the deficits equal, a pattern that has been described for human strabismic amblyopes.
L Kiorpes; D C Kiper; J A Movshon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Vision research     Volume:  33     ISSN:  0042-6989     ISO Abbreviation:  Vision Res.     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1994-02-02     Completed Date:  1994-02-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0417402     Medline TA:  Vision Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2301-11     Citation Subset:  IM    
Department of Psychology, New York University, NY 10003.
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MeSH Terms
Amblyopia / physiopathology*
Anisometropia / physiopathology
Contrast Sensitivity / physiology*
Macaca nemestrina
Pattern Recognition, Visual / physiology
Sensory Thresholds / physiology
Strabismus / physiopathology
Visual Acuity / physiology
Grant Support

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