Document Detail

Contrast sensitivity function in patients with beta-thalassemia major.
MedLine Citation:
PMID:  11037904     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate contrast sensitivity function in patients with beta-thalassemia major, after regular transfusion and chelation therapy. METHODS: We measured contrast sensitivity at four spatial frequencies in 30 patients with beta-thalassemia major and in 30 matched normal control subjects. All subjects underwent an ophthalmic examination that included fluorescein angiography. The contrast sensitivity results from the two groups were compared between them. Patients' contrast sensitivity values were correlated to the variables age, duration of transfusion, duration of chelation therapy and serum ferritin levels, to select the important predictors. RESULTS: Contrast sensitivity function in all beta-thalassemic patients was significantly lower (p<0.0001) compared to the normal control subjects, for all spatial frequencies tested. The most important predictor of contrast sensitivity loss was patients' age. CONCLUSION: Contrast sensitivity testing can detect early changes in the visual function of beta-thalassemic patients and should be considered as a monitor for patients under chronic transfusion-chelation therapy.
S P Gartaganis; N Zoumbos; J X Koliopoulos; E K Mela
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta ophthalmologica Scandinavica     Volume:  78     ISSN:  1395-3907     ISO Abbreviation:  Acta Ophthalmol Scand     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2001-01-11     Completed Date:  2001-01-25     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  9507578     Medline TA:  Acta Ophthalmol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  512-5     Citation Subset:  IM    
Department of Ophthalmology, University of Patras Medical School, Greece.
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MeSH Terms
Blood Transfusion
Chelation Therapy
Contrast Sensitivity / physiology*
Deferoxamine / therapeutic use
Ferritins / blood
Fluorescein Angiography
Middle Aged
Vision Disorders / physiopathology
beta-Thalassemia / blood,  physiopathology*,  therapy
Reg. No./Substance:
70-51-9/Deferoxamine; 9007-73-2/Ferritins

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