Document Detail


Contrast medium injection protocol adjusted for body surface area in combined PET/CT.
MedLine Citation:
PMID:  23423636     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To evaluate the effect of contrast medium dose adjustment for body surface area (BSA) compared with a fixed-dose protocol in combined positron emission tomography (PET) and computed tomography (CT) (PET/CT).
METHODS: One hundred and twenty patients were prospectively included for (18)F-2-deoxy-fluor-glucose ((18)F-FDG)-PET/CT consisting of a non-enhanced and a venous contrast-enhanced CT, both used for PET attenuation correction. The first 60 consecutive patients received a fixed 148-ml contrast medium dose. The second 60 patients received a dose that was based on their calculated BSA. Mean and maximum standardised FDG uptake (SUVmean and SUVmax) and contrast enhancement (HU) were measured at multiple anatomical sites and PET reconstructions were evaluated visually for image quality.
RESULTS: A decrease in the variance of contrast enhancement in the BSA group compared with the fixed-dose group was seen at all anatomical sites. Comparison of tracer uptake SUVmean and SUVmax between the fixed and the BSA group revealed no significant differences at all anatomical sites (all P > 0.05). Comparison of the overall image quality scores between the fixed and the BSA group showed no significant difference (P = 0.753).
CONCLUSIONS: BSA adjustment results in increased interpatient homogeneity of contrast enhancement without affecting PET values. In combined PET/CT, a BSA adjusted contrast medium protocol should be used preferably.
KEY POINTS: • Intravenous contrast medium is essential for many applications of PET/CT • Body surface area adjustment of contrast medium helps standardise contrast enhancement • Underdosing or overdosing of contrast medium will be reduced • PET image quality is not influenced • BSA adjusted contrast medium protocol should be used preferably in combined PET/CT.
Authors:
Florian F Behrendt; Marilou Rebière; Andreas Goedicke; Hubertus Pietsch; Karin Palmowski; Christiane K Kuhl; Felix M Mottaghy; Frederik A Verburg
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-02-20
Journal Detail:
Title:  European radiology     Volume:  23     ISSN:  1432-1084     ISO Abbreviation:  Eur Radiol     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-06     Completed Date:  2014-01-22     Revised Date:  2014-08-26    
Medline Journal Info:
Nlm Unique ID:  9114774     Medline TA:  Eur Radiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1970-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Body Surface Area
Contrast Media / administration & dosage*
Drug Administration Schedule
Female
Fluorodeoxyglucose F18 / diagnostic use
Humans
Image Processing, Computer-Assisted
Injections
Iodine / administration & dosage
Male
Middle Aged
Multimodal Imaging / methods
Positron-Emission Tomography / methods*
Radiopharmaceuticals / diagnostic use
Tomography, X-Ray Computed / methods*
Chemical
Reg. No./Substance:
0/Contrast Media; 0/Radiopharmaceuticals; 0Z5B2CJX4D/Fluorodeoxyglucose F18; 9679TC07X4/Iodine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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