Document Detail

Contrast media-induced ventricular fibrillation. A comparison of Hypaque-76, Hexabrix, and Omnipaque.
MedLine Citation:
PMID:  3403207     Owner:  NLM     Status:  MEDLINE    
Contrast media occasionally produce ventricular fibrillation during coronary angiography. We compared the fibrillatory propensity of the conventional ionic contrast medium, Hypaque-76 (H76) to the low osmolar ionic dimer Hexabrix (HB) and to the nonionic agent Omnipaque (OM) in 20 open chest anesthetized dogs. Intracoronary injection of 6 mL of contrast medium produced spontaneous ventricular fibrillation in four of ten dogs with H76, compared with two of ten with HB, and zero of ten with OM (P = .07). The induction of two premature beats by programmed stimulation of the myocardium during injection of 4 mL of contrast medium produced ventricular fibrillation in ten of ten dogs with H76, compared with three of ten with HB, and zero of ten with OM (P less than .001). Both H76 and HB produced ventricular fibrillation in ten of ten dogs when three premature beats were induced, compared with two of ten dogs with OM (P less than .001). Four mL H76 produced a 109 +/- 18 msec increase in the QT interval, compared with an 82 +/- 17 msec increase with HB, and a 45 +/- 12 msec increase with OM. We conclude that both low osmolar HB and OM are less fibrillatory than the conventional ionic medium H76, and that the nonionic medium OM is less fibrillatory than the ionic dimer contrast medium HB.
Z E Piao; D K Murdock; M H Hwang; R M Raymond; P J Scanlon
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Investigative radiology     Volume:  23     ISSN:  0020-9996     ISO Abbreviation:  Invest Radiol     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-09-22     Completed Date:  1988-09-22     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0045377     Medline TA:  Invest Radiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  466-70     Citation Subset:  IM    
Department of Medicine, Hines Veterans Administration Hospital, IL 60141.
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MeSH Terms
Contrast Media / toxicity*
Coronary Angiography
Diatrizoate / toxicity*
Diatrizoate Meglumine / toxicity*
Drug Combinations / toxicity
Iohexol / toxicity*
Ioxaglic Acid / toxicity*
Ventricular Fibrillation / chemically induced*
Reg. No./Substance:
0/Contrast Media; 0/Drug Combinations; 117-96-4/Diatrizoate; 131-49-7/Diatrizoate Meglumine; 59017-64-0/Ioxaglic Acid; 66108-95-0/Iohexol; 8064-12-8/urovision

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