Document Detail


Contrast media-induced ventricular fibrillation. A comparison of Hypaque-76, Hexabrix, and Omnipaque.
MedLine Citation:
PMID:  3403207     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Contrast media occasionally produce ventricular fibrillation during coronary angiography. We compared the fibrillatory propensity of the conventional ionic contrast medium, Hypaque-76 (H76) to the low osmolar ionic dimer Hexabrix (HB) and to the nonionic agent Omnipaque (OM) in 20 open chest anesthetized dogs. Intracoronary injection of 6 mL of contrast medium produced spontaneous ventricular fibrillation in four of ten dogs with H76, compared with two of ten with HB, and zero of ten with OM (P = .07). The induction of two premature beats by programmed stimulation of the myocardium during injection of 4 mL of contrast medium produced ventricular fibrillation in ten of ten dogs with H76, compared with three of ten with HB, and zero of ten with OM (P less than .001). Both H76 and HB produced ventricular fibrillation in ten of ten dogs when three premature beats were induced, compared with two of ten dogs with OM (P less than .001). Four mL H76 produced a 109 +/- 18 msec increase in the QT interval, compared with an 82 +/- 17 msec increase with HB, and a 45 +/- 12 msec increase with OM. We conclude that both low osmolar HB and OM are less fibrillatory than the conventional ionic medium H76, and that the nonionic medium OM is less fibrillatory than the ionic dimer contrast medium HB.
Authors:
Z E Piao; D K Murdock; M H Hwang; R M Raymond; P J Scanlon
Related Documents :
7434977 - Atrial fibrillation resulting from cardiac trauma.
9539467 - Early discharge of patients with new-onset atrial fibrillation after cardiovascular sur...
2405547 - Thromboembolic complications in atrial fibrillation.
9632447 - An experimental model of sudden death due to low-energy chest-wall impact (commotio cor...
3330027 - Effects of nifedipine on coronary perfusion; recent assessment by parametric digital su...
24267057 - Imaging the myocardium at risk with (99m)tc-lactadherin administered after reperfusion ...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Investigative radiology     Volume:  23     ISSN:  0020-9996     ISO Abbreviation:  Invest Radiol     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-09-22     Completed Date:  1988-09-22     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0045377     Medline TA:  Invest Radiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  466-70     Citation Subset:  IM    
Affiliation:
Department of Medicine, Hines Veterans Administration Hospital, IL 60141.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Angiography
Animals
Contrast Media / toxicity*
Coronary Angiography
Diatrizoate / toxicity*
Diatrizoate Meglumine / toxicity*
Dogs
Drug Combinations / toxicity
Female
Iohexol / toxicity*
Ioxaglic Acid / toxicity*
Male
Ventricular Fibrillation / chemically induced*
Chemical
Reg. No./Substance:
0/Contrast Media; 0/Drug Combinations; 117-96-4/Diatrizoate; 131-49-7/Diatrizoate Meglumine; 59017-64-0/Ioxaglic Acid; 66108-95-0/Iohexol; 8064-12-8/urovision

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Contrast media-induced blood-brain barrier damage. Potentiation by hypertension.
Next Document:  Water-soluble contrast media compared with barium in enteric follow-through. Urinary excretion and r...