Document Detail

Contrast in adenine uptake by chicken and rabbit erythrocytes in vitro.
MedLine Citation:
PMID:  1280189     Owner:  NLM     Status:  MEDLINE    
1. Relative to rabbit erythrocytes, chicken red blood cells exhibit a much greater capacity to utilize [3H]adenine for nucleotide synthesis in vitro, even at 5 degrees C and in the absence of added inorganic phosphate. 2. This difference is largely due to a higher concentration of phosphoribosylpyrophosphate and greater activity of adenine phosphoribosyltransferase in the avian cells. 3. The capacity of avian erythrocytes for utilization of guanine and hypoxanthine is several fold less than that of adenine. 4. The data are consistent with lower activity for hypoxanthine/guanine phosphoribosyltransferase than for adenine phosphoribosyltransferase in intact chicken erythrocytes. 5. The results indicate that reutilization of adenine by chicken erythrocytes may be physiologically significant.
O P Chilson
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  Comparative biochemistry and physiology. Comparative physiology     Volume:  103     ISSN:  -     ISO Abbreviation:  Comp. Biochem. Physiol. Comp. Physiol.     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1992-12-29     Completed Date:  1992-12-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9441449     Medline TA:  Comp Biochem Physiol Comp Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  291-6     Citation Subset:  IM    
Department of Biology, Washington University, St Louis, MO 63130.
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MeSH Terms
Adenine / blood*
Adenine Nucleotides / blood
Adenine Phosphoribosyltransferase / blood
Blood Proteins / metabolism
Cell Membrane Permeability
Chromatography, Thin Layer
Erythrocytes / metabolism*
Guanine / blood
Hypoxanthines / blood
Phosphoribosyl Pyrophosphate / blood
Reg. No./Substance:
0/Adenine Nucleotides; 0/Blood Proteins; 0/Hypoxanthines; 68-94-0/Hypoxanthine; 73-24-5/Adenine; 73-40-5/Guanine; 7540-64-9/Phosphoribosyl Pyrophosphate; EC Phosphoribosyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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