| Contrast enhancement in chest multidetector computed tomography: intraindividual comparison of 300 mg/ml versus 400 mg/ml iodinated contrast medium. | |
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MedLine Citation:
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PMID: 19124099 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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RATIONALE AND OBJECTIVES: We sought to intraindividually compare intravascular contrast enhancement in multidector computed tomography (MDCT) of the chest using contrast media (CM) containing 300 and 400 mg iodine/ml. MATERIALS AND METHODS: Seventy-one patients underwent repeated MDCT scanning of the chest at baseline and follow-up. CM with standard iodine (protocol A: 300 mg iodine/ml; Iopromide 300) and high iodine concentration (protocol B: 400 mg iodine/ml; Iomeprol 400) were used. The iodine delivery rate (1.29 g iodine/s) and total iodine load (37 g iodine) were identical for the two protocols. Contrast enhancement was measured in the right and left ventricles, pulmonary trunk, right and left pulmonary arteries, and ascending and descending aortas. Results were compared using paired t-tests; P values were adjusted using Bonferroni correction (P <or= .005). RESULTS: Contrast enhancement values showed no statistically significant differences between the two protocols at all anatomic sites (all P > .005). In the right ventricle, pulmonary trunk, and right and left pulmonary arteries, higher attenuation values for protocol A were detected compared to protocol B (379.0 +/- 110.5 vs. 349.8 +/- 117.6, 354.5 +/- 112.2 vs 330.9 +/- 118.3, 348.6 +/- 106.0 vs. 321.8 +/- 109.9, and 347.9 +/- 102.4 vs. 321.0 +/- 104.9 HU, respectively). After the lung circulation (left ventricle, ascending aorta, and descending aorta), attenuation values were marginally higher for protocol B. Using both protocols resulted in suitable contrast enhancement with a mean pulmonary attenuation higher than 300 HU. CONCLUSIONS: Using an adapted injection protocol, the administration of 300 and 400 mg iodine CM resulted in a suitable intravascular contrast enhancement in the chest. The use of 400 mg iodine CM does not lead to a statistically significant improvement in contrast enhancement compared to the 300 mg iodine CM. |
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Authors:
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Florian F Behrendt; Cedric Plumhans; Sebastian Keil; Georg Mühlenbruch; Marco Das; Peter Seidensticker; Christina Mutscher; Rolf W Günther; Andreas H Mahnken |
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Publication Detail:
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Type: Comparative Study; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Academic radiology Volume: 16 ISSN: 1878-4046 ISO Abbreviation: Acad Radiol Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-06 Completed Date: 2009-03-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9440159 Medline TA: Acad Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 144-9 Citation Subset: IM |
Affiliation:
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Department of Diagnostic Radiology, University Hospital RWTH Aachen, Aachen, Germany. behrendt@rad.rwth-aachen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Contrast Media / administration & dosage* Dose-Response Relationship, Drug Female Humans Iopamidol / administration & dosage, analogs & derivatives* Male Middle Aged Radiographic Image Enhancement / methods* Radiography, Thoracic / methods* Reproducibility of Results Sensitivity and Specificity Tomography, X-Ray Computed / methods* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 62883-00-5/Iopamidol; 78649-41-9/iomeprol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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