| Contrast-enhanced whole-heart coronary MRI with bolus infusion of gadobenate dimeglumine at 1.5 T. | |
| | |
MedLine Citation:
|
PMID: 21264933 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We sought to investigate the T(1) kinetics of blood and myocardium after three infusion schemes of gadobenate dimeglumine (Gd-BOPTA) and subsequently compared contrast-enhanced whole-heart coronary MRI after a bolus Gd-BOPTA infusion with nonenhanced coronary MRI at 1.5 T. Blood and myocardium T(1) was measured in seven healthy adults, after each underwent three Gd-BOPTA infusion schemes (bolus: 0.2 mmol/kg at 2 mL/sec, hybrid: 0.1 mmol/kg at 2 mL/sec followed by 0.1 mmol/kg at 0.1 mL/sec, and slow: 0.2 mmol/kg at 0.3 mL/sec). Fourteen additional subjects underwent contrast-enhanced coronary MRI with an inversion-recovery steady-state free precession sequence after bolus Gd-BOPTA infusion. Images were compared with nonenhanced T(2) -prepared steady-state free precision whole-heart coronary MRI in signal-to-noise ratio, contrast-to-noise ratio, depicted vessel length, vessel sharpness, and subjective image quality. Bolus and slow infusion schemes resulted in similar T(1) during coronary MRI, whereas the hybrid infusion method yielded higher T(1) values. A bolus infusion of Gd-BOPTA significantly improved signal-to-noise ratio, contrast-to-noise ratio, depicted coronary artery length, and subjective image quality, when all segments were collectively compared but not when compared segment by segment. In conclusion, whole-heart steady-state free precision coronary MRI at 1.5 T can benefit from a bolus infusion of 0.2 mmol/kg Gd-BOPTA. |
| | |
Authors:
|
Peng Hu; Jonathan Chan; Long H Ngo; Jouke Smink; Beth Goddu; Kraig V Kissinger; Lois Goepfert; Thomas H Hauser; Neil M Rofsky; Warren J Manning; Reza Nezafat |
Related Documents
:
|
14746403 - Gadolinium-enhanced computed tomography angiography in multi-detector row computed tomo... 7957283 - Bolus-enhanced renal spiral ct: technique, diagnostic value and drawbacks. 17205443 - Imaging findings in acute invasive pulmonary aspergillosis: clinical significance of th... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-11-30 |
Journal Detail:
|
Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 65 ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-01-25 Completed Date: 2011-05-02 Revised Date: 2012-03-27 |
Medline Journal Info:
|
Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
|
Languages: eng Pagination: 392-8 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Wiley-Liss, Inc. |
Affiliation:
|
Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Contrast Media
/
administration & dosage*,
pharmacokinetics Coronary Vessels / anatomy & histology* Female Humans Infusions, Intravenous Magnetic Resonance Angiography / methods* Male Meglumine / administration & dosage, analogs & derivatives*, diagnostic use, pharmacokinetics Organometallic Compounds / administration & dosage, diagnostic use*, pharmacokinetics Young Adult |
| Grant Support | |
ID/Acronym/Agency:
|
R01 EB008743-01A2/EB/NIBIB NIH HHS; R01 EB008743-02/EB/NIBIB NIH HHS; R01 EB008743-03/EB/NIBIB NIH HHS; R01EB008743-01A2/EB/NIBIB NIH HHS; UL1 RR025758-01/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media; 0/Organometallic Compounds; 113662-23-0/gadobenic acid; 6284-40-8/Meglumine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A simple approach for three-dimensional mapping of baseline cerebrospinal fluid volume fraction.
Next Document: Improving apparent diffusion coefficient estimates and elucidating tumor heterogeneity using Bayesia...