| Contrast-enhanced ultrasound reveals real-time spatial changes in vascular perfusion during early implantation in the macaque uterus. | |
| | |
MedLine Citation:
|
PMID: 21316046 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To use contrast-enhanced ultrasound (CEU) to quantify blood flow in the macaque uterus during early pregnancy. DESIGN: Prospective nonhuman primate study. SETTING: Oregon National Primate Research Center. ANIMALS: Naturally cycling female rhesus macaques (Macaca mulatta). INTERVENTION(S): Female macaques were mated on days 11-14 of the cycle. Females were then imaged by CEU and Doppler ultrasound once every 3 days from day 21 through day 39 of the fertile cycle. MAIN OUTCOME MEASURE(S): Visualization and quantification of uterine vascular perfusion. RESULT(S): CEU identified the primary placental disc and underlying vessels approximately 2 days earlier than Doppler ultrasound was able to observe endometrial thickening. CEU revealed spatial differences in vascular perfusion between the endometrium, myometrium, and endometrial-myometrial (junctional) zone. Myometrium displayed the highest rate of blood flow (>10 mL/min/g tissue). There was less blood flow in the endometrium and junctional zone (<3 mL/min/g). A brief fall in progesterone was observed during early implantation, which was correlated with reduced blood flow to all three uterine compartments, but did not reduce flow to the placenta. CONCLUSIONS: CEU provides a sensitive, noninvasive method to assess vascular perfusion of the uterus during embryo implantation in macaques. We propose CEU as a new diagnostic tool to monitor vascular changes associated with early pregnancy in women. |
| | |
Authors:
|
Christopher S Keator; Jonathan R Lindner; J Todd Belcik; Cecily V Bishop; Ov D Slayden |
Related Documents
:
|
696886 - Hemodynamic effects of electrical stimulation of forebrain angiotensin and osmosensitiv... 3958526 - Blood flow of peripheral nerve effects of dissection, stretching and compression. 1688266 - The physiology of penile erection. 3335246 - Factors affecting the relative viability of centrifascicular and subperineurial axons i... 11268686 - Effects of available sugar on the reproductive fitness and vectorial capacity of the ma... 11379406 - Renal dysfunction in workers exposed to inorganic lead. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: Fertility and sterility Volume: 95 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-03-07 Completed Date: 2011-05-12 Revised Date: 2012-04-02 |
Medline Journal Info:
|
Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
|
Languages: eng Pagination: 1316-21.e1-3 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006-3448, USA. keatorc@ohsu.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Computer Systems* Contrast Media / diagnostic use* Embryo Implantation* / physiology Female Macaca mulatta Pregnancy Prospective Studies Regional Blood Flow / physiology Ultrasonography, Doppler Ultrasonography, Prenatal* / methods Uterus / blood supply*, ultrasonography* |
| Grant Support | |
ID/Acronym/Agency:
|
NCRR 000163//PHS HHS; P51 RR000163-51/RR/NCRR NIH HHS; R01 DK063508-09/DK/NIDDK NIH HHS; R01 HL078610-08/HL/NHLBI NIH HHS; R01 HL078610-09/HL/NHLBI NIH HHS; R01-DK-063508/DK/NIDDK NIH HHS; R01-HL-078610/HL/NHLBI NIH HHS; RC1 HL100659-02/HL/NHLBI NIH HHS; RC1-HL-100659/HL/NHLBI NIH HHS; T32 HD007133-30/HD/NICHD NIH HHS; T32-HD007133/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Morphological embryo assessment: reevaluation.
Next Document: In vivo delivery of FTY720 prevents radiation-induced ovarian failure and infertility in adult femal...