| Contrast-enhanced ultrasound evaluation of radiofrequency ablation of the kidney: reliable imaging of the thermolesion. | |
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MedLine Citation:
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PMID: 15798427 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Radiofrequency ablation (RFA) is limited by the inability to monitor progression of the thermal lesion. Contrast-enhanced ultrasonography (CEUS) imaging has considerable potential as a monitoring modality for RFA. We report our experience using CEUS to evaluate the lesion produced by RFA in a porcine model. MATERIALS AND METHODS: Five pigs underwent laparoscopic RFA twice, spaced by a 1-week interval. Post- RFA ultrasound imaging was performed transcutaneously immediately after ablation. The kidneys were assessed for a contrast void corresponding to the ablated tissue. The kidneys were then harvested and the gross RFA lesions measured to compare lesion size with that measured using CEUS. RESULTS: A clear lesion was identified at the site of each RFA application. As measured by CEUS, the acute lesions averaged 1.8 +/- 0.4, 1.7 +/- 0.4, and 1.8 +/- 0.3 cm in length, height, and width, respectively, compared with 2.0 +/- 0.5, 1.8 +/- 0.4, and 1.9 +/- 0.3 cm, respectively, by measurement in the gross specimen (P = 0.33, 0.13, and 0.44, respectively). At 1 week, the CEUS-measured dimensions of the lesions were 2.7 +/- 0.5, 2.6 +/- 0.6, and 2.6 +/- 0.6 cm, and the gross measurements of the lesion were 2.7 +/- 0.4, 2.7 +/- 0.9, and 2.6 +/- 0.4 cm (P = 0.75, 0.92, and 0.40, respectively). CONCLUSIONS: Contrast-enhanced ultrasonography appears to be an accurate modality for immediate monitoring of RFA defects. Further study is necessary to assess the clinical utility of CEUS for monitoring RFA of small renal lesions. |
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Authors:
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D Brooke Johnson; David A Duchene; Grant D Taylor; Margaret S Pearle; Jeffrey A Cadeddu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of endourology / Endourological Society Volume: 19 ISSN: 0892-7790 ISO Abbreviation: J. Endourol. Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-03-30 Completed Date: 2005-05-31 Revised Date: 2008-05-30 |
Medline Journal Info:
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Nlm Unique ID: 8807503 Medline TA: J Endourol Country: United States |
Other Details:
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Languages: eng Pagination: 248-52 Citation Subset: IM |
Affiliation:
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The Clinical Center for Minimally Invasive Urologic Cancer Treatment, Department of Urology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9110, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Catheter Ablation / methods* Contrast Media Female Fluorocarbons Kidney / surgery*, ultrasonography* Laparoscopy Swine |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Fluorocarbons; 76-19-7/perflutren |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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