| Contrast-enhanced transvaginal sonography of benign versus malignant ovarian masses: preliminary findings. | |
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MedLine Citation:
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PMID: 18577664 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of this prospective study was to evaluate differences in contrast enhancement and contrast enhancement kinetics in benign versus malignant ovarian masses with pulse inversion harmonic transvaginal sonography. METHODS: Seventeen consecutive patients with 23 morphologically abnormal ovarian masses (solid or cystic with papillary excrescences, focally thickened walls, or irregular solid areas) smaller than 10 cm received a microbubble contrast agent intravenously while undergoing pulse inversion harmonic transvaginal sonography. The following parameters were assessed in all tumors: detectable contrast enhancement, time to peak enhancement (wash-in), peak contrast enhancement, half wash-out time, and area under the enhancement curve. Tumor histologic analysis was used to distinguish benign from malignant ovarian tumors. RESULTS: Fourteen benign masses and 9 malignancies were studied. There was a statistically significant difference in the peak enhancement (mean +/- SD, 23.3 +/- 2.8 versus 12.3 +/- 3.9 dB; P < .01), half wash-out time (139.9 +/- 43.6 versus 46.3 +/- 19.7 seconds; P < .01), and area under the enhancement curve (2012.9 +/- 532.9 versus 523.9 +/- 318 seconds(-1); P < .01) in malignant masses compared with benign disease. There was no statistically significant difference in the time to peak enhancement (26.1 +/- 6.3 versus 24.9 +/- 7.6 seconds; P = .07). CONCLUSIONS: Overall, our data showed a significant difference in the contrast enhancement kinetic parameters between benign and malignant ovarian masses. |
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Authors:
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Arthur C Fleischer; Andrej Lyshchik; Howard W Jones; Marta Crispens; Mary Loveless; Rochelle F Andreotti; Phillip K Williams; David A Fishman |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine Volume: 27 ISSN: 0278-4297 ISO Abbreviation: J Ultrasound Med Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-06-25 Completed Date: 2008-12-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8211547 Medline TA: J Ultrasound Med Country: United States |
Other Details:
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Languages: eng Pagination: 1011-8; quiz 1019-21 Citation Subset: IM |
Affiliation:
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Department of Radiology, Vanderbilt University Medical Center, RR-1213 MCN, 1161 21st Ave N, Nashville, TN 37232-2675, USA. arthur.fleischer@vanderbilt.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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diagnosis*,
pathology,
secondary Adult Aged Area Under Curve Breast Neoplasms / pathology* Contrast Media / diagnostic use* Diagnosis, Differential Endosonography / methods* Female Fluorocarbons / diagnostic use Humans Image Enhancement / methods* Image Processing, Computer-Assisted / methods Kinetics Microbubbles Middle Aged Ovarian Diseases / diagnosis Ovarian Neoplasms / diagnosis*, pathology, secondary Ovary / ultrasonography* Prospective Studies Reproducibility of Results Ultrasonography, Doppler, Color / methods |
| Grant Support | |
ID/Acronym/Agency:
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R21 CA 125227-01/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Definity; 0/Fluorocarbons |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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