Document Detail

Contrast-enhanced magnetic resonance imaging reveals early decrease of transmural extent of reperfused acute myocardial infarction.
MedLine Citation:
PMID:  18853097     Owner:  NLM     Status:  MEDLINE    
In patients with myocardial infarction infarct size and transmural extent are of high prognostic value for clinical outcome and recovery of contractile function of the affected myocardium either spontaneously or after revascularisation. Delayed contrast-enhancement magnetic resonance imaging (DCE-MRI) is a non-invasive imaging technique of high accuracy for determination of myocardial infarct size and transmural extent. As decisions whether revascularisation procedures are promising in patients with coronary artery disease are increasingly based on the transmural infarct extent assessed by DCE-MRI we sought to examine whether the timing of MRI after acute myocardial infarction would influence the transmural extent. We performed DCE-imaging on a clinical 1.5 T scanner in patients at day-1 and day-7 after reperfused STEMI. We assessed the total number of segments displaying DCE as well as differentiated by the transmural infarct extent. The total number of affected segments as well as the number of segments with only subendocardial DCE did not change between day-1 and day-7. In contrast, we observed a significant decrease of the number of segments with DCE of > or =75% transmurality and a significant increase of segments with DCE grade III (51%-75% transmurality). We conclude that the transmural infarct extent is not stable over the first days after STEMI which should be taken into account when assessing viability in clinical and research settings.
Constanze Merten; Henning Steen; Christian Kulke; Evangelos Giannitsis; Hugo A Katus
Related Documents :
20882617 - Comparison of segmentation methods for mri measurement of cardiac function in rats.
16115167 - Rotational coronary atherectomy in acute st-segment elevation myocardial infarction.
11518197 - Recording locations in multichannel magnetocardiography and body surface potential mapp...
18298837 - Investigation of the effect of interleukin-1 receptor antagonist (il-1ra) on markers of...
19165437 - Ivabradine: beyond heart rate control.
1515287 - Vasodilator myocardial perfusion imaging: demonstration of local electrophysiological c...
Publication Detail:
Type:  Controlled Clinical Trial; Journal Article     Date:  2008-10-13
Journal Detail:
Title:  Clinical research in cardiology : official journal of the German Cardiac Society     Volume:  97     ISSN:  1861-0692     ISO Abbreviation:  -     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2009-01-21     Completed Date:  2009-03-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264123     Medline TA:  Clin Res Cardiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  913-6     Citation Subset:  IM    
Abteilung Innere Medizin III, Medizinische Klinik, Universitätsklinikum Heidelberg, 69120, Heidelberg, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Contrast Media / diagnostic use*
Gadolinium DTPA / diagnostic use
Magnetic Resonance Imaging / methods*
Middle Aged
Myocardial Infarction / diagnosis*
Myocardial Revascularization / methods*
Time Factors
Reg. No./Substance:
0/Contrast Media; 80529-93-7/Gadolinium DTPA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Reduction of right ventricular pacing in patients with sinus node dysfunction through programming a ...
Next Document:  Semicarbazide-sensitive amine oxidase activity and total nitrite and nitrate concentrations in serum...