Document Detail

Contrast-enhanced first-pass myocardial perfusion magnetic resonance imaging with parallel acquisition at 3.0 Tesla.
MedLine Citation:
PMID:  17507805     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Magnetic resonance imaging (MRI) at 3 T is significantly different than 1.5 T and needs to be optimized due to increased signal-to-noise ratio (SNR) and specific absorption ratio (SAR). This study tests the hypothesis that first-pass myocardial perfusion MRI using saturation recovery (SR)-TrueFISP with parallel imaging is superior to SR-TurboFLASH and a more achievable technique for clinical application at 3 T. MATERIALS AND METHODS: Myocardial perfusion imaging was performed on 12 subjects using SR-TurboFLASH and SR-TrueFISP sequences combined with parallel imaging. Four myocardial slices were acquired and evaluated by image segmentation. Quality of the measurements was determined from SNR, contrast-to-noise ratio (CNR), enhancement-to-noise ratio (ENR), and myocardial perfusion upslope. Data were analyzed using a 2-way ANOVA with imaging method and segment number as the independent variables. RESULTS: SNR, CNR, ENR, and upslope were significantly higher for SR-TrueFISP versus SR-TurboFLASH (P < 0.001). Significant differences in SNR, CNR, ENR, and upslope were found among the myocardial segments (P < 0.005). CONCLUSIONS: Optimized SR-TrueFISP first-pass myocardial perfusion MRI at 3 T has superior image quality compared with SR-TurboFLASH, independent of the myocardial segment analyzed. However, coil sensitivity nonuniformities and dielectric resonance effects cause signal intensity differences between myocardial segments that must be accounted for when interpreting 3 T perfusion studies.
Chun Ruan; Scott H Yang; Kenneth Cusi; Feng Gao; Geoffrey D Clarke
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Investigative radiology     Volume:  42     ISSN:  0020-9996     ISO Abbreviation:  Invest Radiol     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-17     Completed Date:  2007-07-19     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0045377     Medline TA:  Invest Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  352-60     Citation Subset:  IM    
Department of Radiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284-6200, USA.
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MeSH Terms
Analysis of Variance
Contrast Media
Gadolinium DTPA / diagnostic use
Heart Diseases / diagnosis*
Magnetic Resonance Imaging / methods*
Middle Aged
Phantoms, Imaging
Grant Support
Reg. No./Substance:
0/Contrast Media; 122795-43-1/gadodiamide; 80529-93-7/Gadolinium DTPA

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