| Contrast-enhanced dynamic MRI protocol with improved spatial and time resolution for in vivo microimaging of the mouse with a 1.5-T body scanner and a superconducting surface coil. | |
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MedLine Citation:
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PMID: 15833619 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Magnetic resonance imaging (MRI) is well suited for small animal model investigations to study various human pathologies. However, the assessment of microscopic information requires a high-spatial resolution (HSR) leading to a critical problem of signal-to-noise ratio limitations in standard whole-body imager. As contrast mechanisms are field dependent, working at high field do not allow to derive MRI criteria that may apply to clinical settings done in standard whole-body systems. In this work, a contrast-enhanced dynamic MRI protocol with improved spatial and time resolution was used to perform in vivo tumor model imaging on the mouse at 1.5 T. The needed sensitivity is provided by the use of a 12-mm superconducting surface coil operating at 77 K. High quality in vivo images were obtained and revealed well-defined internal structures of the tumor. A 3-D HSR sequence with voxels of 59x59x300 microm3 encoded within 6.9 min and a 2-D sequence with subsecond acquisition time and isotropic in-plane resolution of 234 microm were used to analyze the contrast enhancement kinetics in tumoral structures at long and short time scales. This work is a first step to better characterize and differentiate the dynamic behavior of tumoral heterogeneities. |
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Authors:
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Jean-Christophe Ginefri; Marie Poirier-Quinot; Philippe Robert; Luc Darrasse |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Magnetic resonance imaging Volume: 23 ISSN: 0730-725X ISO Abbreviation: Magn Reson Imaging Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2005-04-18 Completed Date: 2005-08-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8214883 Medline TA: Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 239-43 Citation Subset: IM |
Affiliation:
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Unité de Recherche en Résonance Magnétique Médicale, CNRS, UMR 8081, Bâtiment 220, Université Paris XI, 91405 Orsay, France. jean-christophe.ginefri@u2r2m.u-psud.fr |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Contrast Media Female Gadolinium / diagnostic use Heterocyclic Compounds / diagnostic use Humans Imaging, Three-Dimensional Magnetic Resonance Imaging / instrumentation, methods* Mammary Neoplasms, Experimental / pathology* Mice Mice, Nude Organometallic Compounds / diagnostic use Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Heterocyclic Compounds; 0/Organometallic Compounds; 7440-54-2/Gadolinium; 92923-44-9/gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate |
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