Document Detail

Contrast enhanced color Doppler endorectal sonography of prostate: efficiency for detecting peripheral zone tumors and role for biopsy procedure.
MedLine Citation:
PMID:  12796647     Owner:  NLM     Status:  MEDLINE    
PURPOSE: We evaluated the accuracy of contrast enhanced color Doppler endorectal ultrasound to guide biopsy for the detection of prostate cancer. MATERIALS AND METHODS: A total of 85 patients were evaluated with gray scale and color Doppler before and during intravenous injection of ultrasound contrast agent made of galactose based air microbubbles. Our biopsy protocol was performed during contrast injection. An additional 18 directed cores were obtained based on contrast enhanced imaging. Diagnostic efficiency with and without contrast medium injection for detecting prostate cancer were compared based on biopsy results. RESULTS: Cancer was identified in a total of 58 biopsy sites in 54 patients. Gray scale imaging revealed 96 abnormal hypoechoic nodules or irregular zones inside the outer gland, of which 48 were malignant on pathological evaluation. Contrast enhanced color Doppler had higher sensitivity (93%) than unenhanced color Doppler (54%), while specificity increased only 79% to 87% for enhanced imaging. Nine of 10 isoechoic suspicious zones were depicted with enhancement, while unenhanced Doppler detected 7 of them. There was no significant difference between the intensity of enhancement and tumor Gleason scores. CONCLUSIONS: Contrast enhanced color Doppler endorectal sonography increases the detection of prostate cancer. Improvement in sensitivity was high, while the difference in specificity was not as pertinent. It is accurate when using a common and routine application ultrasound unit. This technique is easy to perform and not time-consuming. Obtaining additional biopsy cores of suspicious enhancing foci significantly improves the detection rate of cancer.
Catherine Roy; Xavier Buy; Herve Lang; Christian Saussine; Didier Jacqmin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of urology     Volume:  170     ISSN:  0022-5347     ISO Abbreviation:  J. Urol.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-06-10     Completed Date:  2003-07-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  69-72     Citation Subset:  AIM; IM    
Department of Radiology B, University Hospital of Strasbourg-Hôpital Civil, 1 place de l'hôpital, 67091 Strasbourg Cedex, France.
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MeSH Terms
Aged, 80 and over
Biopsy, Needle
Endosonography / methods*
Image Enhancement
Middle Aged
Prostate / ultrasonography*
Prostatic Neoplasms / pathology,  ultrasonography*
Sensitivity and Specificity
Ultrasonography, Doppler / methods*
Comment In:
J Urol. 2004 Jun;171(6 Pt 1):2384   [PMID:  15126841 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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