| Contrast-enhanced B-mode US angiography in the assessment of experimental in vivo and in vitro atherosclerotic disease. | |
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MedLine Citation:
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PMID: 11227645 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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RATIONALE AND OBJECTIVES: This study was performed to (a) test the hypothesis that filling the arterial lumen with echoes at B-mode ultrasound (US) enables the assessment of wall and luminal abnormalities and (b) compare contrast material-enhanced B-mode US with color and power Doppler US angiography. MATERIALS AND METHODS: Atherosclerotic lesions were created in 14 rabbit aortas and imaged with color Doppler and B-mode US before and after the intravenous administration of 0.3 mL of AF0150, a US contrast agent. In addition, four replicas of diseased human carotid arteries were immersed in a tissue-mimicking phantom and imaged with B-mode and color and power Doppler US before and after the administration of 1 mL of AF0150 per liter of porcine blood. Radiopaque plastic casts of the rabbit aortas and contact radiographs of the plastic replicas served as standards. RESULTS: Although color and power Doppler US allowed immediate localization of the lumen, precise estimation of stenoses and reliable visualization of surface irregularities were not possible. After AF0150 administration, angiogram-like images of the lumen were created with B-mode US, allowing rapid assessment of the entire vessel lumen and wall. Consequently, luminal stenoses were more accurately measured than with unenhanced B-mode US (r2 = 0.94, P < .0001 vs r2 = 0.21, P = .25) or Doppler (r2 = 0.42, P < .03). In addition, plaques and ulcerations were visible only with contrast-enhanced B-mode US. CONCLUSION: Microbubbles fill the arterial lumen with echoes at B-mode US, creating an angiogram-like image. The ability to visualize the inner and outer surfaces of the vascular wall improved the evaluation of luminal and wall abnormalities. |
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Authors:
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C B Sirlin; Y Z Lee; M S Girard; T M Peterson; G C Steinbach; K G Baker; R F Mattrey |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Academic radiology Volume: 8 ISSN: 1076-6332 ISO Abbreviation: Acad Radiol Publication Date: 2001 Feb |
Date Detail:
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Created Date: 2001-02-28 Completed Date: 2001-05-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9440159 Medline TA: Acad Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 162-72 Citation Subset: IM |
Affiliation:
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Department of Radiology, University of California, San Diego Medical Center, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta, Abdominal / ultrasonography Aortic Diseases / ultrasonography* Arteriosclerosis / ultrasonography* Carotid Arteries / ultrasonography Contrast Media Female Humans Models, Cardiovascular Rabbits Ultrasonography, Doppler, Color |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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