| Contrast-enhanced (18) F-FDG-PET/CT for the assessment of necrotic lymph node metastases. | |
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MedLine Citation:
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PMID: 20652890 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND.: Cystic lymph node metastasis (CLNM) is commonly found in human papillomavirus (HPV)-associated tonsillar squamous cell carcinoma (SCC). The aim of this study was to compare the accuracy in detecting cystic lymph node metastasis from tonsillar SCC between contrast-enhanced CT, (18) F- fluorodeoxyglucose-positron emission tomography (FDG-PET), non-enhanced (18) F-FDG-PET/CT, and contrast-enhanced (18) F-FDG-PET/CT. METHODS.: Thirty-four patients with a tonsillar SCC undergoing a pretreatment contrast-enhanced (18) F-FDG-PET/CT followed by a neck dissection as a standard of reference were included. The contrast-enhanced CT part, the (18) F-FDG-PET part, the non-enhanced (18) F-FDG-PET/CT part, and the contrast-enhanced (18) F-FDG-PET/CT were assessed separately for correct N classification and the differentiation of N0 versus N+. RESULTS.: Contrast-enhanced (18) F-FDG-PET/CT, non-enhanced (18) F-FDG-PET/CT, and contrast-enhanced CT are equally accurate for correct neck staging. Regarding pN0 versus pN+, contrast-enhanced CT and contrast-enhanced (18) F-FDG-PET/CT are superior to non-enhanced (18) F-FDG-PET/CT (p = .017). CONCLUSION.: Contrast-enhanced CT and contrast-enhanced (18) F-FDG-PET/CT perform equally and better than non-enhanced (18) F-FDG-PET/CT in detecting CLNM in tonsillar SCC. Therefore, in patients scheduled for (18) F-FDG-PET/CT, we strongly suggest performing a contrast-enhanced (18) F-FDG-PET/CT, which is not routine in most centers. © 2010 Wiley Periodicals, Inc. Head Neck, 2010. |
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Authors:
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Stephan K Haerle; Klaus Strobel; Nader Ahmad; Alex Soltermann; Daniel T Schmid; Sandro J Stoeckli |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Head & neck Volume: 33 ISSN: 1097-0347 ISO Abbreviation: Head Neck Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8902541 Medline TA: Head Neck Country: United States |
Other Details:
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Languages: eng Pagination: 324-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Wiley Periodicals, Inc. |
Affiliation:
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Department of Otolaryngology, Head and Neck Surgery, University Hospital Zurich, Frauenklinikstrasse 24, CH-8091 Zurich, Switzerland. stephan.haerle@usz.ch. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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