Document Detail

Contrast-dose relation in first-pass myocardial MR perfusion imaging.
MedLine Citation:
PMID:  17520736     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To determine the regime of linear contrast enhancement in human first-pass perfusion cardiovascular magnetic resonance (CMR) imaging to improve accuracy in myocardial perfusion quantification. MATERIALS AND METHODS: A total of 10 healthy subjects were studied on a clinical 1.5T MR scanner. Seven doses of Gd-DTPA ranging from 0.00125 to 0.1 mmol/kg of body weight (b.w.) were administered as equal volumes by rapid bolus injection (6 mL/second). Resting periods of 15 minutes were introduced after delivery of Gd doses >0.01 mmol/kg b.w. For each subject, two series of rest perfusion scans were performed using two different multislice saturation-recovery perfusion sequences. Maximum contrast enhancement and maximum upslope were obtained in the blood pool of the left ventricular (LV) cavity and in the myocardium. The range of linear contrast-dose relation was determined by linear regression analysis. RESULTS: MR signal intensity increased linearly for contrast agent concentrations up to 0.01 mmol/kg b.w. in the LV blood pool and up to 0.05 mmol/kg b.w. in the myocardium. For Gd concentrations exceeding these thresholds the signal intensity response was not linear with respect to the contrast agent dose. CONCLUSION: Quantitative evaluation of cardiac MR perfusion data needs to account for signal saturation in both the LV blood pool and the myocardium.
Wolfgang Utz; Thoralf Niendorf; Ralf Wassmuth; Daniel Messroghli; Rainer Dietz; Jeanette Schulz-Menger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  25     ISSN:  1053-1807     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-28     Completed Date:  2007-08-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1131-5     Citation Subset:  IM    
Copyright Information:
(c) 2007 Wiley-Liss, Inc.
Franz Volhard Klinik, Charite Campus Buch, Helios Klinikum-Berlin at the Max Delbrück Center for Molecular Medicine, Wiltbergstrasse 50, 13125 Berlin, Germany.
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MeSH Terms
Contrast Media / administration & dosage*
Dose-Response Relationship, Drug
Gadolinium DTPA / administration & dosage*
Image Enhancement / methods*
Image Processing, Computer-Assisted
Linear Models
Magnetic Resonance Angiography / methods*
Reg. No./Substance:
0/Contrast Media; 80529-93-7/Gadolinium DTPA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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