| Contrast detection, discrimination and adaptation in patients with Parkinson's disease and multiple system atrophy. | |
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MedLine Citation:
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PMID: 9448577 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Visual spatial contrast thresholds and suprathreshold contrast matches were measured before and after adaptation to high-contrast sinewave gratings in patients with Parkinson's disease (n = 27), patients with multiple system atrophy (n = 6) and a group of age-matched control patients without CNS disease (n = 27). Contrast thresholds were higher in the Parkinson's disease patients than in either the multiple system atrophy patients or control patients. The effect of contrast adaptation on both contrast thresholds and matches was approximately equal in the three groups. This suggests that contrast adaptation is not affected by these CNS disorders and is consistent with the hypothesis that the loss in contrast sensitivity in Parkinson's disease is mediated by retinal effects. The results are discussed in terms of the underlying pathology of the visual deficits in Parkinson's disease and the possible diagnostic implications for differentiating Parkinson's disease and multiple system atrophy. |
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Authors:
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L Tebartz van Elst; M W Greenlee; J M Foley; C H Lücking |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brain : a journal of neurology Volume: 120 ( Pt 12) ISSN: 0006-8950 ISO Abbreviation: Brain Publication Date: 1997 Dec |
Date Detail:
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Created Date: 1998-02-17 Completed Date: 1998-02-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372537 Medline TA: Brain Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 2219-28 Citation Subset: AIM; IM |
Affiliation:
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Neurologische Universitätsklinik, Universität Freiburg, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Ocular* Contrast Sensitivity* Discrimination (Psychology) Evoked Potentials, Visual Humans Multiple System Atrophy / physiopathology* Parkinson Disease / physiopathology* Photic Stimulation Reaction Time Reference Values Severity of Illness Index Vision, Binocular Visual Perception* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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