| Contradictory functions of sulfatide in the blood coagulation system as coagulant and anticoagulant. | |
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MedLine Citation:
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PMID: 9821878 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sulfatide (galactosylceramide I3 -sulfate) has been reported to activate blood coagulation factor XII (Hageman factor), which suggests that it exhibits coagulant activity (Fujikama et al., 1980 Biochemistry 19, 1322-1330) However, sulfatide administered into animals as a bolus shot without subsequent thrombus formation, prolonged conventional clotting times and bleeding time (Hara et al., 1996 Glycoconjugate J. 13, 187-194). These findings suggest that it may exhibit anticoagulant rather than coagulant activity. Following this suggestion we found in vitro that binding of sulfatide to fibrinogen resulted in disturbance of fibrin formation. To examine a possible pharmacological effect of sulfatide on blood coagulation in vivo we continuously infused sulfatide into rats through plastic cannulae and found formation of giant thrombi around the tips of the cannulae. These data suggest that sulfatide may exhibit contradictory functions in the blood coagulation system. |
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Authors:
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M Kyogashima; J Onaya; A Hara; T Taketomi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta biochimica Polonica Volume: 45 ISSN: 0001-527X ISO Abbreviation: Acta Biochim. Pol. Publication Date: 1998 |
Date Detail:
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Created Date: 1999-01-20 Completed Date: 1999-01-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 14520300R Medline TA: Acta Biochim Pol Country: POLAND |
Other Details:
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Languages: eng Pagination: 493-9 Citation Subset: IM |
Affiliation:
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Seikagaku Corporation Tokyo Research Institute, Japan. kyogashimamo@ma4.justnet.ne.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticoagulants / metabolism, pharmacology Blood Coagulation* / drug effects Coagulants / metabolism, pharmacology Humans Rats Sulfoglycosphingolipids* / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Coagulants; 0/Sulfoglycosphingolipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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