| Contradictory effects of β1- and α1- aderenergic receptor blockers on cardio-ankle vascular stiffness index (CAVI)--CAVI independent of blood pressure. | |
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MedLine Citation:
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PMID: 21071883 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: The cardio-ankle vascular stiffness index (CAVI) is a new parameter that reflects the stiffness of the aorta, femoral artery and tibial artery as a whole. One of its conspicuous features is that CAVI is independent of blood pressure at measuring time, theoretically. But, it has not been experimentally proved yet. For confirmation, pharmacological studies were performed comparing with brachial-ankle pulse wave velocity (baPWV). METHODS: Used drugs were a β1-adrenoceptor blocker, metoprorol and an α1- adrenoceptor blocker doxazosin. Both were administered to 12 healthy volunteer men. CAVI and baPWV were measured every one hour for 6 hours using VaSera. RESULTS: When metoprolol (80 mg) was administered to 12 healthy volunteer men, systolic blood pressure decreased from 131.4 ± 4.5 to 118.3 ± 4.1 mmHg (mean ± SE) (p < 0.05) at the 3rd hour, and diastolic blood pressure decreased from 85.3 ± 4.0 to 75.3 ± 3.0 mm Hg (p < 0.05). baP-WV decreased from 13.93 ± 0.46 to 12.46 ± 0.49 m/sec (p < 0.05), significantly, but CAVI did not change (8.16 ± 0.29 to 8.24 ± 0.27) (p = 0.449). ΔbaPWV at each time was significantly correlated with both Δsystolic and Δdiastolic blood pressures, but ΔCAVI was not correlated with either Δblood pressure. When doxazosin (4 mg) was administered to the same men, systolic blood pressure decreased from 130.2 ± 4.6 to 117.2 ± 4.8 mmHg (p < 0.05) at the 3rd hour. Diastolic blood pressure also decreased from 85.1 ± 4.1 to 74.2 ± 3.9 mmHg (p < 0.05). baPWV decreased from 13.98 ± 0.68 to 12.25 ± 0.53 m/sec (p < 0.05), significantly. CAVI also decreased from 8.15 ± 0.28 to 7.18 ± 0.37 (p < 0.05), significantly. CONCLUSION: These results suggested that CAVI was not affected by blood pressure at the measuring time directly, but affected by the changes of contractility of smooth muscle cells. |
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Authors:
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Kohji Shirai; Mingling Song; Jun Suzuki; Takumi Kurosu; Tomokazu Oyama; Daiji Nagayama; Yoh Miyashita; Shigeo Yamamura; Mao Takahashi |
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Publication Detail:
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Type: Journal Article Date: 2010-11-06 |
Journal Detail:
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Title: Journal of atherosclerosis and thrombosis Volume: 18 ISSN: 1880-3873 ISO Abbreviation: J. Atheroscler. Thromb. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-02-01 Completed Date: 2011-05-31 Revised Date: 2011-10-05 |
Medline Journal Info:
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Nlm Unique ID: 9506298 Medline TA: J Atheroscler Thromb Country: Japan |
Other Details:
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Languages: eng Pagination: 49-55 Citation Subset: IM |
Affiliation:
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Internal Medicine, Sakura Hospital, School of Medicine, Toho University, Chiba, Japan. kshirai@kb3.so-net.ne.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Antagonists
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pharmacology* Adrenergic beta-Antagonists / pharmacology* Adult Ankle Brachial Index* Blood Pressure / drug effects* Humans Male Middle Aged Receptors, Adrenergic, alpha-1 / drug effects* Receptors, Adrenergic, beta-1 / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Antagonists; 0/Adrenergic beta-Antagonists; 0/Receptors, Adrenergic, alpha-1; 0/Receptors, Adrenergic, beta-1 |
| Comments/Corrections | |
Comment In:
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J Atheroscler Thromb. 2011 Aug 24;18(8):720; author reply 721-2
[PMID:
21532238
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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