| Contractures in skeletal muscle of malignant hyperthermia susceptible patients after in vitro exposure to sevoflurane. | |
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MedLine Citation:
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PMID: 10714850 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Sevoflurane, a potent inhalational anaesthetic agent that is structurally similar to halothane, has some favourable characteristics, but may also be able to trigger malignant hyperthermia (MH) in susceptible patients. The diagnosis of malignant hyperthermia susceptibility relies on the in vitro contracture test on skeletal muscle. The present study was undertaken to investigate whether exposure to sevoflurane of muscles of malignant hyperthermia susceptible (MHS) patients would also cause an abnormal contracture. METHODS: Muscle fascicles obtained from three MHS patients, one malignant hyperthermia non-susceptible (MHN) patient, two control patients and one malignant hyperthermia equivocal (MHE) patient were exposed to sevoflurane instead of halothane in the in vitro contracture test, carried out according to the protocol of the European Malignant Hyperthermia Group. The muscle fascicles were surplus to diagnostic requirements. Sevoflurane concentrations in the testbath were measured using a headspace gas chromatographic technique. RESULTS: The kinetics of sevoflurane concentration in the testbath were similar to those of halothane. An in vitro contracture response of 2 mN or more was seen in all four MHS/MHE patients with sevoflurane but not in the three control/MHN patients. The magnitude of muscle contracture in the sevoflurane test was less than in the conventional halothane test at comparable testbath concentrations. CONCLUSIONS: Sevoflurane can trigger an abnormal contracture in human muscle in vitro. This is indicative of malignant hyperthermia susceptibility. Exposure to sevoflurane should be avoided in patients thought to be susceptible to malignant hyperthermia. |
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Authors:
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M M Snoeck; M J Gielen; A Tangerman; J van Egmond; R Dirksen |
Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Acta anaesthesiologica Scandinavica Volume: 44 ISSN: 0001-5172 ISO Abbreviation: Acta Anaesthesiol Scand Publication Date: 2000 Mar |
Date Detail:
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Created Date: 2000-03-23 Completed Date: 2000-03-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370270 Medline TA: Acta Anaesthesiol Scand Country: DENMARK |
Other Details:
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Languages: eng Pagination: 334-7 Citation Subset: IM |
Affiliation:
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Department of Anaesthesiology, University Hospital Nijmegen, The Netherlands. Anesthesie@cwz.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthetics, Inhalation
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adverse effects* Caffeine / pharmacology Humans Malignant Hyperthermia / etiology* Methyl Ethers / adverse effects* Muscle Contraction / drug effects* Muscle, Skeletal / drug effects*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 0/Methyl Ethers; 28523-86-6/sevoflurane; 58-08-2/Caffeine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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