Document Detail

Contractions to endothelin in normotensive and spontaneously hypertensive rats: role of endothelium and prostaglandins.
MedLine Citation:
PMID:  1345142     Owner:  NLM     Status:  MEDLINE    
Contractions to endothelin-1 in aortas of the spontaneously hypertensive rats (SHR) were compared with those of normotensive controls (WKY); rings with and without endothelium were studied in organ chambers. Contractions to endothelin were smaller in aortas of SHR compared to WKY, whether the endothelium was present or not. The presence of a functional endothelium reduced contractions to the peptide in both strains. Endothelium-dependent relaxations to acetylcholine and endothelium-independent relaxations to nitric oxide were observed in rings from both strains during contraction with endothelin. Indomethacin reduced the contractions to endothelin in the aorta from SHR with endothelium, but not in those without endothelium; it did not significantly affect endothelin-induced contractions in rings of WKY with or without endothelium. These experiments demonstrate that contractions of the vascular smooth muscle to endothelin are reduced in the aorta of the SHR. The basal and stimulated release of endothelium-derived relaxing factor inhibits contractions to endothelin in the aorta from both strains. The inhibitor of cyclooxygenase indomethacin does not prevent the response of the vascular smooth muscle to endothelin; however, endothelin may stimulate the release of an indomethacin-sensitive endothelium-derived contracting factor in the SHR aorta.
W Auch-Schwelk; P M Vanhoutte
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Blood pressure     Volume:  1     ISSN:  0803-7051     ISO Abbreviation:  Blood Press.     Publication Date:  1992 May 
Date Detail:
Created Date:  1994-06-27     Completed Date:  1994-06-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9301454     Medline TA:  Blood Press     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  45-9     Citation Subset:  IM    
Baylor College of Medicine, Houston, Texas.
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MeSH Terms
Acetylcholine / pharmacology
Aorta / drug effects*
Endothelins / pharmacology*
Endothelium, Vascular / physiology*
Indomethacin / pharmacology
Nitric Oxide / pharmacology
Prostaglandins / physiology*
Rats, Inbred SHR / physiology*
Rats, Inbred WKY
Reference Values
Vasoconstriction* / drug effects
Grant Support
Reg. No./Substance:
0/Endothelins; 0/Prostaglandins; 10102-43-9/Nitric Oxide; 51-84-3/Acetylcholine; 53-86-1/Indomethacin

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