| Contractions of postmortem human saphenous veins perfused with pulsatile flow. | |
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MedLine Citation:
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PMID: 3491819 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to evaluate the contractions of postmortem human saphenous veins under pulsatile flow conditions as a simulation of coronary-aortic bypass graft (CABG) surgery. Twenty-five cylindrical specimens of veins, obtained from 20 cadavers several hours after death, were mounted in a pulsatile flow system with a pulse rate of 80/min and a mean flow rate of 7 ml/min at various perfusion pressures. Prostaglandin F2 alpha(PGF2 alpha) was then applied to the outer physiological salt solution at a concentration of 3 X 10(-6) mol. Of the 25 veins, 18 (72%) contracted and seven did not. Contractions were observed at a mean perfusion pressure of less than 60 mmHg but not at higher pressures. Three contraction patterns were observed: One caused pressure gradients between the proximal and distal sites of the vein and showed periodic contractions (P); one showed only tonic contractions (T); the other showed pulse pressure increase without developing the pressure gradients (PP). The incidences of P, T, and PP in the 18 instances of contraction were 50%, 33%, and 17%, respectively. Repeated applications of PGF2 alpha to the same vein with the same and/or increased perfusion pressure caused changes of pattern in the direction of P to T, to PP, and to no response, whereas decreasing perfusion pressure caused the patterns to change in the reverse direction. The pressure gradients that developed in veins showing P and T patterns correlated well with the mean perfusion pressure (r = 0.68, P less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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T Iino; K Kawasaki; N Nakanishi; I Miyazawa; S Hosoda |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Heart and vessels Volume: 2 ISSN: 0910-8327 ISO Abbreviation: Heart Vessels Publication Date: 1986 |
Date Detail:
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Created Date: 1987-02-05 Completed Date: 1987-02-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8511258 Medline TA: Heart Vessels Country: JAPAN |
Other Details:
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Languages: eng Pagination: 154-60 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Flow Velocity Blood Pressure Coronary Artery Bypass Dinoprost Female Humans Male Middle Aged Muscle Contraction* / drug effects Perfusion Postmortem Changes Prostaglandins F / pharmacology Pulsatile Flow* Rheology* Saphenous Vein / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins F; 551-11-1/Dinoprost |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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