Document Detail

Contractions of postmortem human saphenous veins perfused with pulsatile flow.
MedLine Citation:
PMID:  3491819     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to evaluate the contractions of postmortem human saphenous veins under pulsatile flow conditions as a simulation of coronary-aortic bypass graft (CABG) surgery. Twenty-five cylindrical specimens of veins, obtained from 20 cadavers several hours after death, were mounted in a pulsatile flow system with a pulse rate of 80/min and a mean flow rate of 7 ml/min at various perfusion pressures. Prostaglandin F2 alpha(PGF2 alpha) was then applied to the outer physiological salt solution at a concentration of 3 X 10(-6) mol. Of the 25 veins, 18 (72%) contracted and seven did not. Contractions were observed at a mean perfusion pressure of less than 60 mmHg but not at higher pressures. Three contraction patterns were observed: One caused pressure gradients between the proximal and distal sites of the vein and showed periodic contractions (P); one showed only tonic contractions (T); the other showed pulse pressure increase without developing the pressure gradients (PP). The incidences of P, T, and PP in the 18 instances of contraction were 50%, 33%, and 17%, respectively. Repeated applications of PGF2 alpha to the same vein with the same and/or increased perfusion pressure caused changes of pattern in the direction of P to T, to PP, and to no response, whereas decreasing perfusion pressure caused the patterns to change in the reverse direction. The pressure gradients that developed in veins showing P and T patterns correlated well with the mean perfusion pressure (r = 0.68, P less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
T Iino; K Kawasaki; N Nakanishi; I Miyazawa; S Hosoda
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Heart and vessels     Volume:  2     ISSN:  0910-8327     ISO Abbreviation:  Heart Vessels     Publication Date:  1986  
Date Detail:
Created Date:  1987-02-05     Completed Date:  1987-02-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8511258     Medline TA:  Heart Vessels     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  154-60     Citation Subset:  IM    
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MeSH Terms
Blood Flow Velocity
Blood Pressure
Coronary Artery Bypass
Middle Aged
Muscle Contraction* / drug effects
Postmortem Changes
Prostaglandins F / pharmacology
Pulsatile Flow*
Saphenous Vein / physiology*
Reg. No./Substance:
0/Prostaglandins F; 551-11-1/Dinoprost

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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