| Contractility patterns of human leg lymphatics in various stages of obstructive lymphedema. | |
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MedLine Citation:
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PMID: 18519964 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In healthy human leg, lymphatics contract spontaneously, rhythmically propelling lymph. The pressures generated by lymphatic contractions constitute the main force for lymph flow. This mechanism is of utmost importance during night rest, anesthesia, and immobilization, as well as in those with damaged peripheral motor neurons. Under physiological conditions, limb muscular activity and position only slightly change lymph flow. In obstructive lymphedema, lymphatic wall muscular fibers become damaged and the spontaneous contractility becomes ineffective in lymph transport because of low generated pressures and lymphatic valve insufficiency. The lymph-propelling task is taken over by leg muscle contractions. Measuring intralymphatic pressures and flow gives some insight into the mechanism of lymph flow in healthy limbs and loss of this function in lymphedema. This knowledge will be useful in the derivation of rational treatments for lymphedema. |
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Authors:
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Waldemar L Olszewski |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 1131 ISSN: 0077-8923 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-06-03 Completed Date: 2008-07-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 110-8 Citation Subset: IM |
Affiliation:
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Department of Surgical Research and Transplantology, Medical Research Center, Polish Academy of Sciences, 5 Pawinskiego Str., 02 106 Warsaw, Poland. wlo@cmdik.pan.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Humans Leg / pathology* Lymph / physiology Lymphatic System / pathology*, physiology* Lymphedema / physiopathology* Muscle Contraction / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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