Document Detail

Contractility patterns of human leg lymphatics in various stages of obstructive lymphedema.
MedLine Citation:
PMID:  18519964     Owner:  NLM     Status:  MEDLINE    
In healthy human leg, lymphatics contract spontaneously, rhythmically propelling lymph. The pressures generated by lymphatic contractions constitute the main force for lymph flow. This mechanism is of utmost importance during night rest, anesthesia, and immobilization, as well as in those with damaged peripheral motor neurons. Under physiological conditions, limb muscular activity and position only slightly change lymph flow. In obstructive lymphedema, lymphatic wall muscular fibers become damaged and the spontaneous contractility becomes ineffective in lymph transport because of low generated pressures and lymphatic valve insufficiency. The lymph-propelling task is taken over by leg muscle contractions. Measuring intralymphatic pressures and flow gives some insight into the mechanism of lymph flow in healthy limbs and loss of this function in lymphedema. This knowledge will be useful in the derivation of rational treatments for lymphedema.
Waldemar L Olszewski
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1131     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2008  
Date Detail:
Created Date:  2008-06-03     Completed Date:  2008-07-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  110-8     Citation Subset:  IM    
Department of Surgical Research and Transplantology, Medical Research Center, Polish Academy of Sciences, 5 Pawinskiego Str., 02 106 Warsaw, Poland.
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MeSH Terms
Leg / pathology*
Lymph / physiology
Lymphatic System / pathology*,  physiology*
Lymphedema / physiopathology*
Muscle Contraction / physiology*

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