Document Detail

Contractility of intrarenal arteries in Goldblatt hypertensive rabbits.
MedLine Citation:
PMID:  2161793     Owner:  NLM     Status:  MEDLINE    
The present investigation contractile responses of microdissected intrarenal arcuate arteries from sham-operated rabbits and two-kidney, one clip Goldblatt hypertensive rabbits at 2 and 12 weeks after procedure. Arcuate arteries from both kidneys of the sham-operated rabbits and stenotic and nonstenotic kidneys of the Goldblatt hypertensive rabbits were studied. Mean arterial blood pressures of the sham-operated and Goldblatt hypertensive rabbits were 72 +/- 2 and 85 +/- 2, and 130 +/- 3 and 125 +/- 4 mm Hg at 2 weeks and 12 weeks, respectively. In vitro isometric contractile force measurements were made with a small-artery myograph. Responses to graded concentrations of norepinephrine were evoked in the arcuate arteries, and the maximum active force was developed and -log EC50 was determined. At 2 weeks after procedure, the maximum responses of the vessels from the left kidney of the sham-operated rabbits and those from the stenotic left kidney of the Goldblatt hypertensive rabbits did not differ. The responses of the vessels from the right kidney of the sham-operated rabbits did not differ from those of the nonstenotic right kidney of the hypertensive rabbits. A markedly depressed maximum response of the vessels from the nonstenotic kidney of the hypertensive as compared with the right kidney of the sham-operated rabbits was found at 12 weeks after procedure, whereas the vessels from the stenotic kidney of the hypertensive and the left kidney of the sham-operated rabbits exhibited almost identical maximal responses. Responses to U 46619 were similarly affected in the two groups of rabbits. Cold-induced contractile responses of the arcuate arteries from the nonstenotic kidney of the hypertensive rabbits did not differ from those of the sham-operated rabbits at the 12-week interval.(ABSTRACT TRUNCATED AT 250 WORDS)
N D McElroy; B G Zimmerman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension     Volume:  15     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-07-13     Completed Date:  1990-07-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  753-60     Citation Subset:  IM    
Department of Pharmacology, University of Minnesota Medical School, Minneapolis.
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MeSH Terms
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Arteries / drug effects,  metabolism
Cold Temperature
Hypertension, Renovascular / metabolism,  physiopathology*
Phosphatidylinositols / metabolism
Prostaglandin Endoperoxides, Synthetic / pharmacology
Renal Circulation*
Sympathomimetics / pharmacology
Vasoconstrictor Agents / pharmacology
Reg. No./Substance:
0/Phosphatidylinositols; 0/Prostaglandin Endoperoxides, Synthetic; 0/Sympathomimetics; 0/Vasoconstrictor Agents; 76898-47-0/15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid

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