Document Detail


Contractile responses to hypoxia of isolated rings from the left branch of rabbit pulmonary artery.
MedLine Citation:
PMID:  2722115     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Contractile responses of left extrapulmonary artery segments with either intact or damaged endothelium were examined with changes in PO2 at constant pH. Hypoxia consistently reduced noradrenaline-induced contractions. This hypoxia-induced relaxation was sometimes followed by a contraction and a second relaxation. Hypoxia-induced relaxations were also obtained if precontraction was elicited with KCl (40 mM), but no triphasic response was observed. Relaxations faded away with time and only contractions were then observed. Relaxations were more considerable in rings from young animals and, although always present, decreased with the age of the animal. Endothelium damage reduced hypoxia-induced relaxations. Indomethacin, a potent blocker of cyclooxygenase, increased hypoxia-induced contraction and reduced relaxation in segments with intact endothelium. Without endothelium the indomethacin effect was less significant. It is concluded that the response to hypoxia of the pulmonary artery is similar to that of systemic vessels. Endothelium seems to play a modulatory role in the hypoxia-induced response in extrapulmonary artery. Prostaglandin metabolism seems to play a minor role in this modulation.
Authors:
P Bonnet; J A Argibay; D Garnier
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Fundamental & clinical pharmacology     Volume:  3     ISSN:  0767-3981     ISO Abbreviation:  Fundam Clin Pharmacol     Publication Date:  1989  
Date Detail:
Created Date:  1989-07-05     Completed Date:  1989-07-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8710411     Medline TA:  Fundam Clin Pharmacol     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  115-26     Citation Subset:  IM    
Affiliation:
Laboratoire d'Electrophysiologie et de Pharmacologie Cellulaires, Université de Tours, France.
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / pharmacology
Animals
Anoxia / physiopathology*
Arachidonic Acids / metabolism
Diethylcarbamazine / pharmacology
Endothelium, Vascular / drug effects
Male
Muscle Contraction / drug effects
Muscle Relaxation / drug effects
Muscle, Smooth, Vascular / drug effects*
Norepinephrine / pharmacology
Potassium Chloride / pharmacology
Pulmonary Artery / drug effects
Rabbits
Chemical
Reg. No./Substance:
0/Arachidonic Acids; 51-41-2/Norepinephrine; 51-84-3/Acetylcholine; 7447-40-7/Potassium Chloride; 90-89-1/Diethylcarbamazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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