| Contractile responses to histamine, serotonin, and angiotensin II are impaired by 17 beta-estradiol in human internal mammary arteries in vitro. | |
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MedLine Citation:
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PMID: 9127439 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is accumulating evidence that estrogen replacement therapy protects against the development of coronary atherosclerosis and myocardial infarction in postmenopausal women. The mechanism of this protective effect is uncertain. The purpose of the present study was to determine whether 17 beta-estradiol acutely modifies vascular smooth muscle contractile responses to various agonists in human arteries in vitro. Human mammary artery rings were obtained during aortocoronary bypass operations. Rings were suspended in organ baths for isometric tension measurements. Concentration response curves induced by serotonin (0.01-30 mumol/l), histamine (0.01-300 mumol/l), and angiotensin II (0.1-100 nmol/l) were generated after pre-incubation for 30 min with either 17 beta-estradiol (3 mumol/l) or solvent (0.2% ethanol). The presence of 17 beta-estradiol significantly reduced the maximal contractile effects induced by histamine, serotonin, and angiotensin II, but not by 80 mmol/l potassium chloride. It is concluded that short-term incubation with 17 beta-estradiol reduces the maximal contractile responses to serotonin, histamine, and angiotensin II. These modulating effects of estrogen on vascular tone may contribute to the proposed beneficial role of estrogen replacement therapy on the incidence of myocardial infarction in postmenopausal women. |
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Authors:
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A Mügge; M Barton; H G Fieguth; M Riedel |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Pharmacology Volume: 54 ISSN: 0031-7012 ISO Abbreviation: Pharmacology Publication Date: 1997 Mar |
Date Detail:
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Created Date: 1997-07-10 Completed Date: 1997-07-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0152016 Medline TA: Pharmacology Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 162-8 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Hannover Medical School, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angiotensin II / pharmacology* Coronary Artery Bypass Dose-Response Relationship, Drug Estradiol / pharmacology* Estrogen Replacement Therapy Female Histamine / pharmacology* Humans Male Mammary Arteries / drug effects, metabolism Middle Aged Muscle Contraction / drug effects Muscle, Smooth, Vascular / drug effects*, metabolism Potassium Chloride / adverse effects Serotonin / pharmacology* |
| Chemical | |
Reg. No./Substance:
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11128-99-7/Angiotensin II; 50-28-2/Estradiol; 50-67-9/Serotonin; 51-45-6/Histamine; 7447-40-7/Potassium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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