Document Detail

Contractile responses to histamine, serotonin, and angiotensin II are impaired by 17 beta-estradiol in human internal mammary arteries in vitro.
MedLine Citation:
PMID:  9127439     Owner:  NLM     Status:  MEDLINE    
There is accumulating evidence that estrogen replacement therapy protects against the development of coronary atherosclerosis and myocardial infarction in postmenopausal women. The mechanism of this protective effect is uncertain. The purpose of the present study was to determine whether 17 beta-estradiol acutely modifies vascular smooth muscle contractile responses to various agonists in human arteries in vitro. Human mammary artery rings were obtained during aortocoronary bypass operations. Rings were suspended in organ baths for isometric tension measurements. Concentration response curves induced by serotonin (0.01-30 mumol/l), histamine (0.01-300 mumol/l), and angiotensin II (0.1-100 nmol/l) were generated after pre-incubation for 30 min with either 17 beta-estradiol (3 mumol/l) or solvent (0.2% ethanol). The presence of 17 beta-estradiol significantly reduced the maximal contractile effects induced by histamine, serotonin, and angiotensin II, but not by 80 mmol/l potassium chloride. It is concluded that short-term incubation with 17 beta-estradiol reduces the maximal contractile responses to serotonin, histamine, and angiotensin II. These modulating effects of estrogen on vascular tone may contribute to the proposed beneficial role of estrogen replacement therapy on the incidence of myocardial infarction in postmenopausal women.
A Mügge; M Barton; H G Fieguth; M Riedel
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Pharmacology     Volume:  54     ISSN:  0031-7012     ISO Abbreviation:  Pharmacology     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-07-10     Completed Date:  1997-07-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0152016     Medline TA:  Pharmacology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  162-8     Citation Subset:  IM    
Division of Cardiology, Hannover Medical School, Germany.
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MeSH Terms
Angiotensin II / pharmacology*
Coronary Artery Bypass
Dose-Response Relationship, Drug
Estradiol / pharmacology*
Estrogen Replacement Therapy
Histamine / pharmacology*
Mammary Arteries / drug effects,  metabolism
Middle Aged
Muscle Contraction / drug effects
Muscle, Smooth, Vascular / drug effects*,  metabolism
Potassium Chloride / adverse effects
Serotonin / pharmacology*
Reg. No./Substance:
11128-99-7/Angiotensin II; 50-28-2/Estradiol; 50-67-9/Serotonin; 51-45-6/Histamine; 7447-40-7/Potassium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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