Document Detail


Contractile response to colonic distention is influenced by oscillation frequency.
MedLine Citation:
PMID:  15670266     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Static colonic mechanical properties are characterized by stepwise balloon distention. It is unclear whether the state of contractile activation affects frequency-dependent differences in biomechanical properties. Our aim was to investigate the frequency-dependence of colonic mechanical properties by sinusoidal oscillation. A descending colonic balloon was sinusoidally oscillated by 25 mL at 5, 10 and 20 cpm in randomized order for 20 min at each frequency in six healthy subjects before and after neostigmine. Volume oscillation was between 75-100 mL before, and 25-50 mL after neostigmine. Pressure waveforms were most variable shortly after commencing oscillation, reflecting an initial contractile response to distention. Elastance (i.e. pressure response to imposed volume) and hysteresivity were estimated; hysteresivity represents the proportion of energy added to the system during inflation, which cannot be recovered during deflation. Colonic elastance was frequency dependent, being highest and most variable at 10 cpm. In contrast, hysteresivity was not significantly different across frequencies. Neostigmine increased mean colonic elastance at all frequencies, and hysteresivity only at 5 cpm. Thus, colonic mechanical properties, particularly elastance are frequency-dependent. The frequency-dependence of colonic mechanical properties is worthy of future study because it may provide insights into reflex responses in health and disease.
Authors:
A E Bharucha; S Dhamija; A Japp; B Seide; B Walters; R Stroetz; A R Zinsmeister; R D Hubmayr
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society     Volume:  17     ISSN:  1350-1925     ISO Abbreviation:  Neurogastroenterol. Motil.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-01-26     Completed Date:  2005-03-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9432572     Medline TA:  Neurogastroenterol Motil     Country:  England    
Other Details:
Languages:  eng     Pagination:  64-75     Citation Subset:  IM    
Affiliation:
Gastroenterology Research Unit, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA. Bharucha.adil@mayo.edu
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / pharmacology
Adult
Balloon Dilatation
Cholinesterase Inhibitors / pharmacology
Colon / drug effects,  physiology*
Elasticity
Female
Humans
Male
Middle Aged
Muscle Contraction / drug effects,  physiology
Muscle, Smooth / drug effects,  physiology*
Neostigmine / pharmacology
Physical Stimulation
Plethysmography
Pressure
Reproducibility of Results
Grant Support
ID/Acronym/Agency:
R01 HD38666/HD/NICHD NIH HHS; R01 HD41129/HD/NICHD NIH HHS; RR00585/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Cholinesterase Inhibitors; 51-84-3/Acetylcholine; 59-99-4/Neostigmine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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