Document Detail

Contractile response to colonic distention is influenced by oscillation frequency.
MedLine Citation:
PMID:  15670266     Owner:  NLM     Status:  MEDLINE    
Static colonic mechanical properties are characterized by stepwise balloon distention. It is unclear whether the state of contractile activation affects frequency-dependent differences in biomechanical properties. Our aim was to investigate the frequency-dependence of colonic mechanical properties by sinusoidal oscillation. A descending colonic balloon was sinusoidally oscillated by 25 mL at 5, 10 and 20 cpm in randomized order for 20 min at each frequency in six healthy subjects before and after neostigmine. Volume oscillation was between 75-100 mL before, and 25-50 mL after neostigmine. Pressure waveforms were most variable shortly after commencing oscillation, reflecting an initial contractile response to distention. Elastance (i.e. pressure response to imposed volume) and hysteresivity were estimated; hysteresivity represents the proportion of energy added to the system during inflation, which cannot be recovered during deflation. Colonic elastance was frequency dependent, being highest and most variable at 10 cpm. In contrast, hysteresivity was not significantly different across frequencies. Neostigmine increased mean colonic elastance at all frequencies, and hysteresivity only at 5 cpm. Thus, colonic mechanical properties, particularly elastance are frequency-dependent. The frequency-dependence of colonic mechanical properties is worthy of future study because it may provide insights into reflex responses in health and disease.
A E Bharucha; S Dhamija; A Japp; B Seide; B Walters; R Stroetz; A R Zinsmeister; R D Hubmayr
Related Documents :
17841716 - Teleseismic search for slow precursors to large earthquakes.
22294046 - Rapidly-exploring roadmaps: weighing exploration vs. refinement in optimal motion plann...
21708706 - Stick insects walking along inclined surfaces.
20396006 - Spatial-frequency response of gamma ruticons.
15518206 - A single mechanism for both luminance and chromatic grating vernier tasks: evidence fro...
22122956 - High-frequency audiometry: a means for early diagnosis of noise-induced hearing loss.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society     Volume:  17     ISSN:  1350-1925     ISO Abbreviation:  Neurogastroenterol. Motil.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-01-26     Completed Date:  2005-03-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9432572     Medline TA:  Neurogastroenterol Motil     Country:  England    
Other Details:
Languages:  eng     Pagination:  64-75     Citation Subset:  IM    
Gastroenterology Research Unit, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acetylcholine / pharmacology
Balloon Dilatation
Cholinesterase Inhibitors / pharmacology
Colon / drug effects,  physiology*
Middle Aged
Muscle Contraction / drug effects,  physiology
Muscle, Smooth / drug effects,  physiology*
Neostigmine / pharmacology
Physical Stimulation
Reproducibility of Results
Grant Support
Reg. No./Substance:
0/Cholinesterase Inhibitors; 51-84-3/Acetylcholine; 59-99-4/Neostigmine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A randomized-controlled trial comparing an educational intervention alone vs education and biofeedba...
Next Document:  Effects of the selective serotonin reuptake inhibitor, fluoxetine, on regional gastric contractility...