| Contractile reactivity of human myometrium in isolated non-pregnant uteri. | |
| | |
MedLine Citation:
|
PMID: 16155074 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Perfusion of the isolated uterus has been shown to be a feasible experimental system for studies of the human endometrium and myometrium. Utilizing our established experimental perfusion model we perfused 20 uteri for 27 h and investigated the contractile reactivity of the myometrium in response to 17beta-estradiol (E2) and oxytocin (OT). METHODS: Uteri of group A (n = 4) were stimulated with OT; group B (n = 4) was treated continuously with E2; group C (n = 4) received both E2 and OT for 27 h; group D (n = 4) was perfused for 27 h with E2 with the addition of OT for the last 3 h of the experiment; group E (n = 4) as control group remained without any treatment. The pressure and duration of uterine contractions were recorded during the entire perfusion period using intramural and endoluminal pressure catheters. RESULTS: Compared to the other treatment groups and controls, the most effective myometrial activity was achieved in group D during the OT stimulation period. No relevant myometrial activity was detected in the control group. CONCLUSIONS: Continuous E2 treatment, with the addition of OT for the last 3 h of the 27 h perfusion period, led to the most pronounced uterotonic effects in the presented experimental condition. |
| | |
Authors:
|
O N Richter; C Bartz; J Dowaji; M Kupka; J Reinsberg; U Ulrich; W Rath |
Related Documents
:
|
20221744 - Effects of fluids on microvascular perfusion in patients with severe sepsis. 2045934 - Brain perfusion is abnormal in cocaine-dependent polydrug users: a study using techneti... 2653874 - Response of skin photoplethysmography, laser doppler flowmetry and transcutaneous oxyge... 2501284 - Reduction of lung perfusion increases va/q heterogeneity. 8069014 - Efficacy and adverse effects of transpulmonary contrast echocardiography using sonicate... 14732734 - Daily nighttime melatonin reduces blood pressure in male patients with essential hypert... |
Publication Detail:
|
Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't Date: 2005-09-09 |
Journal Detail:
|
Title: Human reproduction (Oxford, England) Volume: 21 ISSN: 0268-1161 ISO Abbreviation: Hum. Reprod. Publication Date: 2006 Jan |
Date Detail:
|
Created Date: 2005-12-05 Completed Date: 2006-02-27 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: England |
Other Details:
|
Languages: eng Pagination: 36-45 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynaecology, University of Aachen School of Medicine, Aachen, Germany. orichter@ukaachen.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Estradiol
/
pharmacology Female Humans Muscle Contraction / physiology* Myometrium / drug effects*, physiology Oxytocin / pharmacology* Perfusion Uterine Contraction / physiology* Uterus / drug effects*, physiology |
| Chemical | |
Reg. No./Substance:
|
50-28-2/Estradiol; 50-56-6/Oxytocin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: 17beta-estradiol suppresses proliferation of fibroblasts derived from cardinal ligaments in patients...
Next Document: Preimplantation genetic screening reveals a high incidence of aneuploidy and mosaicism in embryos fr...