Document Detail

Contractile reactivity of human myometrium in isolated non-pregnant uteri.
MedLine Citation:
PMID:  16155074     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Perfusion of the isolated uterus has been shown to be a feasible experimental system for studies of the human endometrium and myometrium. Utilizing our established experimental perfusion model we perfused 20 uteri for 27 h and investigated the contractile reactivity of the myometrium in response to 17beta-estradiol (E2) and oxytocin (OT). METHODS: Uteri of group A (n = 4) were stimulated with OT; group B (n = 4) was treated continuously with E2; group C (n = 4) received both E2 and OT for 27 h; group D (n = 4) was perfused for 27 h with E2 with the addition of OT for the last 3 h of the experiment; group E (n = 4) as control group remained without any treatment. The pressure and duration of uterine contractions were recorded during the entire perfusion period using intramural and endoluminal pressure catheters. RESULTS: Compared to the other treatment groups and controls, the most effective myometrial activity was achieved in group D during the OT stimulation period. No relevant myometrial activity was detected in the control group. CONCLUSIONS: Continuous E2 treatment, with the addition of OT for the last 3 h of the 27 h perfusion period, led to the most pronounced uterotonic effects in the presented experimental condition.
O N Richter; C Bartz; J Dowaji; M Kupka; J Reinsberg; U Ulrich; W Rath
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-09-09
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  21     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-05     Completed Date:  2006-02-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  36-45     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, University of Aachen School of Medicine, Aachen, Germany.
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MeSH Terms
Estradiol / pharmacology
Muscle Contraction / physiology*
Myometrium / drug effects*,  physiology
Oxytocin / pharmacology*
Uterine Contraction / physiology*
Uterus / drug effects*,  physiology
Reg. No./Substance:
50-28-2/Estradiol; 50-56-6/Oxytocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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