Document Detail


Contraceptive efficacy and safety of DMPA-SC.
MedLine Citation:
PMID:  15451329     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
DMPA-SC 104 mg/0.65 mL is a new, low-dose subcutaneous (SC) formulation of Depo-Provera contraceptive injection (150 mg/mL medroxyprogesterone acetate injectable suspension) that provides efficacy, safety and immediacy of onset equivalent to Depo-Provera intramuscular (IM) injection. Two large, open-label, Phase 3 studies assessed the 1-year contraceptive efficacy, safety and patient satisfaction with DMPA-SC administered every 3 months (12-13 weeks). Zero pregnancies were reported in both studies, which included a total of 16,023 woman-cycles of exposure to DMPA-SC and substantial numbers of overweight or obese women. DMPA-SC was well-tolerated and adverse events were similar to those reported previously with Depo-Provera IM. Thus, DMPA-SC offers women a new, highly effective and convenient long-acting contraceptive option.
Authors:
J Jain; A J Jakimiuk; F R Bode; D Ross; A M Kaunitz
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Publication Detail:
Type:  Clinical Trial; Clinical Trial, Phase III; Journal Article    
Journal Detail:
Title:  Contraception     Volume:  70     ISSN:  0010-7824     ISO Abbreviation:  Contraception     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-09-28     Completed Date:  2005-01-18     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0234361     Medline TA:  Contraception     Country:  United States    
Other Details:
Languages:  eng     Pagination:  269-75     Citation Subset:  IM    
Copyright Information:
Copyright 2004 Elsevier Inc.
Affiliation:
Department of Obstetrics and Gynecology, University of Southern California, Keck School of Medicine, 1240 North Mission Road, Room 8K6, Los Angeles, CA, USA. jjain@usc.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Amenorrhea / epidemiology
Asia
Blood Pressure
Body Mass Index
Body Weight
Contraceptive Agents, Female / administration & dosage*,  adverse effects*
Europe
Female
Humans
Injections, Subcutaneous
Medroxyprogesterone Acetate / administration & dosage*,  adverse effects*
Patient Satisfaction
Pregnancy
United States
Uterine Hemorrhage / epidemiology
Chemical
Reg. No./Substance:
0/Contraceptive Agents, Female; 71-58-9/Medroxyprogesterone Acetate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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