| Contraceptive efficacy and safety of DMPA-SC. | |
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MedLine Citation:
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PMID: 15451329 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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DMPA-SC 104 mg/0.65 mL is a new, low-dose subcutaneous (SC) formulation of Depo-Provera contraceptive injection (150 mg/mL medroxyprogesterone acetate injectable suspension) that provides efficacy, safety and immediacy of onset equivalent to Depo-Provera intramuscular (IM) injection. Two large, open-label, Phase 3 studies assessed the 1-year contraceptive efficacy, safety and patient satisfaction with DMPA-SC administered every 3 months (12-13 weeks). Zero pregnancies were reported in both studies, which included a total of 16,023 woman-cycles of exposure to DMPA-SC and substantial numbers of overweight or obese women. DMPA-SC was well-tolerated and adverse events were similar to those reported previously with Depo-Provera IM. Thus, DMPA-SC offers women a new, highly effective and convenient long-acting contraceptive option. |
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Authors:
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J Jain; A J Jakimiuk; F R Bode; D Ross; A M Kaunitz |
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Publication Detail:
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Type: Clinical Trial; Clinical Trial, Phase III; Journal Article |
Journal Detail:
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Title: Contraception Volume: 70 ISSN: 0010-7824 ISO Abbreviation: Contraception Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-09-28 Completed Date: 2005-01-18 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0234361 Medline TA: Contraception Country: United States |
Other Details:
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Languages: eng Pagination: 269-75 Citation Subset: IM |
Copyright Information:
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Copyright 2004 Elsevier Inc. |
Affiliation:
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Department of Obstetrics and Gynecology, University of Southern California, Keck School of Medicine, 1240 North Mission Road, Room 8K6, Los Angeles, CA, USA. jjain@usc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amenorrhea / epidemiology Asia Blood Pressure Body Mass Index Body Weight Contraceptive Agents, Female / administration & dosage*, adverse effects* Europe Female Humans Injections, Subcutaneous Medroxyprogesterone Acetate / administration & dosage*, adverse effects* Patient Satisfaction Pregnancy United States Uterine Hemorrhage / epidemiology |
| Chemical | |
Reg. No./Substance:
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0/Contraceptive Agents, Female; 71-58-9/Medroxyprogesterone Acetate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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