| Contraceptive efficacy of a combined oral contraceptive containing ethinyloestradiol 20μg/drospirenone 3mg administered in a 24/4 regimen: a pooled analysis of four open-label studies. | |
| | |
MedLine Citation:
|
PMID: 21277674 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: To determine the contraceptive efficacy of a low-dose combined oral contraceptive containing ethinyloestradiol (EE) 20μg/drospirenone (drsp) 3mg administered for 24 days followed by a four-day hormone-free interval (24/4 regimen), by pooling data from four clinical trials. STUDY DESIGN: Data on the occurrence of pregnancy during treatment in four open-label trials that enrolled healthy female volunteers aged 17-36 years, who received EE 20μg/drsp 3mg in a 24/4 regimen for 7 or 13 cycles, were pooled. RESULTS: Sixteen pregnancies occurred among 2386 women during 729,537 days (26,055 cycles) of treatment exposure, resulting in a Pearl Index (PI) of 0.80 (upper two-sided 95% confidence interval (CI) limit of 1.30). Of these pregnancies, seven were defined as method failures, resulting in an adjusted PI of 0.41 (upper two-sided 95% CI limit of 0.85), based on 616,607 days (22,022 cycles) of treatment. The Kaplan-Meier estimate for the one-year cumulative probability of contraceptive protection was 99.21%. CONCLUSIONS: The EE 20μg/drsp 3mg combined oral contraceptive administered in a 24/4 regimen has acceptable contraceptive efficacy. |
| | |
Authors:
|
Leena Anttila; Gloria Bachmann; László Hernádi; Michael Kunz; Joachim Marr; Christine Klipping |
Related Documents
:
|
23375234 - Is the placental disk really an ellipse? 6360224 - Thymidine factor in human cord sera and relationship to birth size, gestational age and... 22854674 - India is on the way forward to maternal and neonatal tetanus elimination! 2470014 - Accuracy of two wavelength pulse oximetry in neonates and infants. 23392264 - Early life nutritional programming of obesity: mother-child cohort studies. 20638334 - Ivf twins have similar obstetric and neonatal outcome as spontaneously conceived twins:... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-1-28 |
Journal Detail:
|
Title: European journal of obstetrics, gynecology, and reproductive biology Volume: - ISSN: 1872-7654 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-1-31 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011. Published by Elsevier Ireland Ltd. |
Affiliation:
|
The Family Federation of Finland, Turku Clinic, Turku, Finland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Twin pregnancies: guidelines for clinical practice from the French College of Gynaecologists and Obs...
Next Document: Quantitative and nutritional characterization of fruit and vegetable waste from marketplace: A poten...