Document Detail

Contraception and breast cancer.
MedLine Citation:
PMID:  21213517     Owner:  NLM     Status:  In-Process    
Oral contraceptive use is weakly associated with breast cancer risk in the general population, but the association among women with a familial predisposition to breast cancer is less clear. Recent studies indicating that oral contraception may increase the risk of breast cancer more in subjects who are BRCA 1 or BRCA 2 mutation carriers. Features of hormonal contraceptive use, such as duration of use, age at first use, and the dose and type of hormone within the contraceptives, have little effect on breast cancer risk. Women who begin use before age 20 have higher relative risks of having breast cancer diagnosed while they are using combined oral contraceptives and in the 5 years after stopping than do women who begin use at older ages. Given that on influence of oral contraceptives on the breast has been hypothesized to be greatest before the cellular differentiation that occurs with a first pregnancy. A significant trend of increasing risk with first use before age 20 years was observed. Among women diagnosed at ages 30 to 34 years the relative risk associated with recent oral contraceptive use was 1.54 if use began before age 20 years and 1.13 it use began at older ages.
Kris Bhothisuwan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the Medical Association of Thailand = Chotmaihet thangphaet     Volume:  87 Suppl 3     ISSN:  0125-2208     ISO Abbreviation:  J Med Assoc Thai     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2011-01-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7507216     Medline TA:  J Med Assoc Thai     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  S167-8     Citation Subset:  IM    
Department of Surgery, Faculty of Medicine, Siriraj Hospital, Bangkok 10700, Thailand.
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