Document Detail

Continuous-wave Doppler in children with ventricular septal defect: noninvasive estimation of interventricular pressure gradient.
MedLine Citation:
PMID:  3946259     Owner:  NLM     Status:  MEDLINE    
Continuous-wave Doppler was used to estimate the pressure gradient between the right and left ventricles in 28 children with ventricular septal defect (VSD). Doppler measurement of maximal velocity was performed during cardiac catheterization and the Doppler-predicted gradient was compared with the peak-to-peak gradient measured simultaneously by catheter. Doppler gradients ranged from 10 to 71 mm Hg and correlated well with measured gradient (r = 0.97, p greater than or equal to 0.001). Fourteen patients had isolated VSD, and in these patients Doppler measurements of gradient allowed accurate estimation of right ventricular pressure (r = 0.93). There was an inverse correlation between the ratio of pulmonary to systemic resistance and maximal velocity (r = -0.77). Thus, continuous-wave Doppler is an accurate means of measuring instantaneous VSD pressure gradient in children with congenital heart disease and can be used to estimate the right ventricular and pulmonary artery pressure in children with isolated VSD. This noninvasive method can be used to distinguish restrictive from nonrestrictive VSD.
D J Murphy; A Ludomirsky; J C Huhta
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of cardiology     Volume:  57     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-03-17     Completed Date:  1986-03-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  428-32     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure*
Child, Preschool
Heart Catheterization
Heart Defects, Congenital / complications
Heart Septal Defects, Ventricular / complications,  physiopathology*
Heart Ventricles / physiopathology
Grant Support

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