Document Detail

Continuous versus intermittent angiotensin converting enzyme inhibition in renal hypertensive rats.
MedLine Citation:
PMID:  8340154     Owner:  NLM     Status:  MEDLINE    
Converting enzyme inhibitors impair renal function of the kidney beyond a stenosis of the renal artery in humans and induce histological lesions in the clipped kidney of renal hypertensive rats. In two-kidney, one clip hypertensive rats, we compared the time course and magnitude of the biochemical effects of angiotensin converting enzyme inhibition on the plasma renin-angiotensin system, cardiac hypertrophy, renal lesions, and 24-hour blood pressure decrease induced by either intermittent angiotensin converting enzyme inhibition administration (benazepril PO, 10 mg/kg once a day, n = 93) or continuous administration (benazeprilat, 3 mg/kg per day via osmotic pumps, n = 92). Control rats (n = 91) received the drug vehicle intermittently or continuously. Mortality was significantly reduced by both intermittent (n = 3/93) and continuous (n = 3/92) inhibition compared with controls (n = 18/91) (P < .001). Changes in the plasma renin-angiotensin system and blood pressure were parallel. A continuous suppression of the activity of the plasma renin-angiotensin system was associated with a 24-hour decrease in blood pressure with continuous inhibition, whereas intermittent inhibition induced a similar fall in blood pressure only for the first hours after gavage.(ABSTRACT TRUNCATED AT 250 WORDS)
T Battle; C Schnell; B Bunkenburg; D Heudes; J M Wood; J Ménard
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension     Volume:  22     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-09-02     Completed Date:  1993-09-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  188-96     Citation Subset:  IM    
Cardiovascular Research, CIBA-GEIGY Ltd., Basel, Switzerland.
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MeSH Terms
Angiotensin II / blood
Angiotensin-Converting Enzyme Inhibitors / pharmacology*
Benzazepines / blood,  pharmacology*
Blood Pressure / drug effects
Creatinine / blood
Heart Rate / drug effects
Hypertension, Renovascular / blood,  pathology,  physiopathology*
Kidney / drug effects,  pathology,  physiopathology
Myocardium / pathology
Organ Size
Rats, Wistar
Renin / blood
Urea / blood
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Benzazepines; 11128-99-7/Angiotensin II; 57-13-6/Urea; 60-27-5/Creatinine; 86541-75-5/benazepril; EC

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