Document Detail


Continuous systolic blood pressure monitoring by the difference in electrocardiogram and pulse oximetry in near-term, exteriorized goat fetuses.
MedLine Citation:
PMID:  12759148     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Our purpose was to determine whether systolic arterial pressure, as predicted from the delay time from the electrocardiogram to pulse oximeter waveform, correlates with directly measured systolic blood pressure. METHODS: Six Japanese Saanen goats at 120-125 days' gestation were used. Experiments were conducted in acutely operated animals under anesthesia. We placed catheters in the carotid artery and jugular vein, electrodes on the chest, and a pulse oximeter probe on the tongue. Systolic blood pressure (Psm), fetal heart rate (FHR), delay time (Td), and pulse oximeter waveform were monitored continuously, and the data were stored. Systolic blood pressure was estimated (Pse) by the simple linear equation of Td. Fetal blood pressure was decreased 10% by hydralazine and blood withdrawal. Correlation coefficients and the agreement between Psm and Pse were determined. RESULTS: A significant correlation (P <.01) with good bias values (< 8 mmHg) and precision values (< 5 mmHg) was obtained between Psm and Pse in all animals. There was also a significant correlation between Psm and Pse with high coefficients for hydralazine (r(2) = 0.82 +/- 0.12) and for withdrawal (r(2) = 0.85 +/- 0.15). The correlations became slightly scattered in acidemia (pH < 7.25). CONCLUSIONS: This technique has the potential to provide information on fetal blood pressure during labor and delivery on a beat-by-beat basis, which will aid in the interpretation of electronic FHR recordings.
Authors:
Hiroshi Sameshima; Yasuyuki Kawagoe; Tsuyomu Ikenoue; Hiroshi Sakamoto
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the Society for Gynecologic Investigation     Volume:  10     ISSN:  1071-5576     ISO Abbreviation:  J. Soc. Gynecol. Investig.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-21     Completed Date:  2004-02-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9433806     Medline TA:  J Soc Gynecol Investig     Country:  United States    
Other Details:
Languages:  eng     Pagination:  200-4     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology and Perinatal Center, Miyazaki Medical College, Miyazaki, Japan. hsameshima@fc.miyazaki-med.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Gas Analysis
Blood Pressure Determination / methods*
Electrocardiography / methods*
Female
Fetal Monitoring / methods*
Goats / embryology*
Heart / embryology*,  physiology
Heart Rate, Fetal / physiology
Hydralazine / pharmacology
Hydrogen-Ion Concentration
Linear Models
Oximetry / methods*
Pregnancy
Vasodilator Agents / pharmacology
Chemical
Reg. No./Substance:
0/Vasodilator Agents; 86-54-4/Hydralazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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