| Continuous subcutaneous insulin infusion versus multiple daily injections in pregnant women with type 1 diabetes. | |
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MedLine Citation:
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PMID: 20210564 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Continuous subcutaneous insulin infusion (CSII) may be an alternative to multiple daily injections (MDI) in pre-gestational diabetes during pregnancy. However, no clear improvement in obstetric and perinatal outcome has so far been established for CSII treatment. METHODS: In a case-control study, 35 pregnancies treated with CSII and 64 pregnancies treated with MDI treatment were evaluated. Metabolic control and obstetric and perinatal outcome were compared. RESULTS: Women in the CSII group improved their metabolic control (hemoglobin A1c before CSII, 7.83 +/- 0.97%; 3-6 months after, 6.77 +/- 0.61%; P < 0.05). Hemoglobin A1c before pregnancy was lower in the CSII group (6.62 +/- 0.60%) than in the MDI group (7.59 +/- 1.61%) (P < 0.05). No other significant differences, either in metabolic control of diabetes or in obstetric and perinatal outcome, were found. CONCLUSIONS: CSII treatment is safe in pregnancy, but it has not yet been associated with any improved pregnancy outcome. |
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Authors:
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Stella Gonz?lez-Romero; Inmaculada Gonz?lez-Molero; Micaela Fern?ndez-Abell?n; Marta E Dom?nguez-L?pez; Soledad Ruiz-de-Adana; Gabriel Olveira; Federico Soriguer |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Diabetes technology & therapeutics Volume: 12 ISSN: 1557-8593 ISO Abbreviation: Diabetes Technol. Ther. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-09 Completed Date: 2010-06-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100889084 Medline TA: Diabetes Technol Ther Country: United States |
Other Details:
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Languages: eng Pagination: 263-9 Citation Subset: IM |
Affiliation:
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Endocrinology and Nutrition, Hospital Regional Universitario Carlos Haya, Avenida del Dr. G?lvez Ginachero S/N, Malaga, Spain. stellagr@telefonica.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Case-Control Studies Diabetes Mellitus, Type 1 / drug therapy* Female Humans Hypoglycemic Agents / administration & dosage* Injections Insulin / administration & dosage, analogs & derivatives* Insulin Infusion Systems* Pregnancy Pregnancy in Diabetics* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Hypoglycemic Agents; 11061-68-0/Insulin; 133107-64-9/insulin LISPRO |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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