| Continuous rotigotine administration reduces dyskinesia resulting from pulsatile treatment with rotigotine or L-DOPA in MPTP-treated common marmosets. | |
| | |
MedLine Citation:
|
PMID: 19833125 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We previously showed that continuous infusion of rotigotine resulted in less dyskinesia than repeated pulsatile rotigotine administration or repeated oral administration of L-DOPA in MPTP-treated marmosets. Now we investigate whether continuous rotigotine delivery modifies established dyskinesia induced by prior exposure to repeated pulsatile administration of L-DOPA or rotigotine in MPTP-treated common marmosets. Repeated oral administration of L-DOPA or subcutaneous bolus administration of rotigotine over 28 days improved motor deficits but resulted in the onset of dyskinesia of moderate intensity. When these animals were switched to a 28-day continuous infusion of rotigotine, the reversal of motor disability was maintained. In those animals initially treated with L-DOPA, there was a small reduction in dyskinesia intensity but a significant reduction in the duration of dyskinesia. However, in animals initially treated with repeated bolus administration of rotigotine, dyskinesia intensity was significantly reduced. Initial treatment with a continuous infusion of rotigotine for 28 days reversed motor disability and resulted in a low incidence of dyskinesia. On switching to repeated oral administration of L-DOPA, the improvement in motor disability was maintained but the propensity of L-DOPA to provoke dyskinesia was not affected. In addition, while the continuous delivery of rotigotine prevented the expression of dyskinesia, the previously demonstrated ability of dopamine agonists to prime for dyskinesia could not be avoided. These data suggest that dyskinesia induced by pulsatile drug treatment may be improved by switching to continuous rotigotine delivery. In addition, while continuous delivery of rotigotine may prime for dyskinesia, it does not lead to its expression. |
| | |
Authors:
|
K A Stockwell; D K A Scheller; L A Smith; S Rose; M M Iravani; M J Jackson; P Jenner |
Related Documents
:
|
17934805 - Long-term l-dopa treatment causes indiscriminate increase in dopamine levels at the cos... 8788255 - Differential effects of the intraventricular administration of 6-hydroxydopamine on the... 2413325 - The protective effect of 1-tert.butyl-4,4-diphenylpiperidine against the nigrostriatal ... 8839975 - In vivo microdialysis to determine the relative pharmacokinetics of drugs. 3137585 - Failure of non-selective inhibition of arachidonic acid metabolism to ameliorate hypero... 18308295 - Caffeic acid phenethyl ester protects rabbit brains against permanent focal ischemia by... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-10-13 |
Journal Detail:
|
Title: Experimental neurology Volume: 221 ISSN: 1090-2430 ISO Abbreviation: Exp. Neurol. Publication Date: 2010 Jan |
Date Detail:
|
Created Date: 2010-01-27 Completed Date: 2010-02-16 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370712 Medline TA: Exp Neurol Country: United States |
Other Details:
|
Languages: eng Pagination: 79-85 Citation Subset: IM |
Affiliation:
|
Neurodegenerative Disease Research Centre, School of Health and Biomedical Sciences, King's College, London, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Callithrix Disability Evaluation Disease Models, Animal Dopamine Agents / administration & dosage*, adverse effects, pharmacology* Drug Administration Schedule Drug Delivery Systems Dyskinesia, Drug-Induced* Female Levodopa / adverse effects* MPTP Poisoning / drug therapy Male Motor Activity / drug effects* Statistics, Nonparametric Tetrahydronaphthalenes / administration & dosage*, adverse effects, pharmacology* Thiophenes / administration & dosage*, adverse effects, pharmacology* Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Dopamine Agents; 0/Levodopa; 0/Tetrahydronaphthalenes; 0/Thiophenes; 92206-54-7/N 0437 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Held under arrest: Many mature albino RPE cells display polyploidal features consistent with abnorma...
Next Document: Roles of channels and receptors in the growth cone during PNS axonal regeneration.