Document Detail


Continuous rhamnolipid production using denitrifying pseudomonas aeruginosa cells in hollow fiber bioreactor.
MedLine Citation:
PMID:  23359613     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Rhamnolipids are high-value effective biosurfactants produced by Pseudomonas aeruginosa. Large scale production of rhamnolipids is still challenging especially under free-cell aerobic conditions in which the highly foaming nature of the culture broth reduces the productivity of the process. Immobilized systems relying on oxygen as electron acceptor have been previously investigated but oxygen transfer limitation presents difficulties for continuous rhamnolipid production. A coupled system using immobilized cells and nitrate instead of oxygen as electron acceptor taking advantage of the ability of P. aeruginosa to perform nitrate respiration was evaluated. This denitrification-based immobilized approach based on a hollow fiber set-up eliminated the transfer limitation problems and was found suitable for continuous rhamnolipid production in a period longer than 1,500 h. It completely eliminated the foaming difficulties related to aerobic systems with a comparable specific productivity of 0.017 g/(g dry cells)-h and allowed easy recovery of rhamnolipids from the cell-free medium. © 2013 American Institute of Chemical Engineers Biotechnol. Prog., 2013.
Authors:
Neissa M Pinzon; Aaron G Cook; Lu-Kwang Ju
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-28
Journal Detail:
Title:  Biotechnology progress     Volume:  -     ISSN:  1520-6033     ISO Abbreviation:  Biotechnol. Prog.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8506292     Medline TA:  Biotechnol Prog     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 American Institute of Chemical Engineers (AIChE).
Affiliation:
Department of Chemical and Biomolecular Engineering, The University of Akron, Akron, OH 44325-3906.
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