| Continuous renal replacement therapy amino acid, trace metal and folate clearance in critically ill children. | |
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MedLine Citation:
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PMID: 19183946 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: We hypothesized continuous veno-venous hemodialysis (CVVHD) amino acid, trace metals and folate clearance impacts nutrient balance. METHODS: Critically ill children receiving CVVHD were studied prospectively for 5 days. Blood concentrations (amino acids, copper, zinc, manganese, chromium, selenium and folate) were measured at CVVHD initiation, and Days 2 and 5. CVVHD clearance, losses and nutrient balances were calculated on Days 2 and 5. RESULTS: We studied 15 children aged 7.7 +/- 6.7 years. Nitrogen balance was negative on Days 2 and 5. Amino acid clearances ranged from 2.8 to 51.1 ml/min per 1.73 m(2). CVVHD losses corresponded to 20% of intake. Days 2 and 5 balances were negative for selenium, but positive for other trace metals. Folate clearance was 16 ml/min per 1.73 m(2) on Days 2 and 5 and serum concentrations decreased significantly from initiation to Day 5 (P < 0.05). CONCLUSIONS: Nutrient losses by CVHHD may impact adequate nutrition provision. |
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Authors:
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Michael Zappitelli; Marisa Juarez; L Castillo; Jorge Coss-Bu; Stuart L Goldstein |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-01-29 |
Journal Detail:
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Title: Intensive care medicine Volume: 35 ISSN: 1432-1238 ISO Abbreviation: Intensive Care Med Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-03-18 Completed Date: 2009-07-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7704851 Medline TA: Intensive Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 698-706 Citation Subset: IM |
Affiliation:
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Renal Section, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Amino Acids / metabolism* Child Child, Preschool Critical Illness* Energy Intake Female Folic Acid / metabolism* Humans Infant Infant, Newborn Intensive Care Units, Pediatric Kidney Failure / therapy* Male Metabolic Clearance Rate / physiology* Metals / metabolism* Nutritional Status Prospective Studies Renal Dialysis / methods Renal Replacement Therapy / methods* Trace Elements / metabolism* Vitamins Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Metals; 0/Trace Elements; 0/Vitamins; 59-30-3/Folic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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