Document Detail

Continuous renal replacement therapy amino acid, trace metal and folate clearance in critically ill children.
MedLine Citation:
PMID:  19183946     Owner:  NLM     Status:  MEDLINE    
PURPOSE: We hypothesized continuous veno-venous hemodialysis (CVVHD) amino acid, trace metals and folate clearance impacts nutrient balance. METHODS: Critically ill children receiving CVVHD were studied prospectively for 5 days. Blood concentrations (amino acids, copper, zinc, manganese, chromium, selenium and folate) were measured at CVVHD initiation, and Days 2 and 5. CVVHD clearance, losses and nutrient balances were calculated on Days 2 and 5. RESULTS: We studied 15 children aged 7.7 +/- 6.7 years. Nitrogen balance was negative on Days 2 and 5. Amino acid clearances ranged from 2.8 to 51.1 ml/min per 1.73 m(2). CVVHD losses corresponded to 20% of intake. Days 2 and 5 balances were negative for selenium, but positive for other trace metals. Folate clearance was 16 ml/min per 1.73 m(2) on Days 2 and 5 and serum concentrations decreased significantly from initiation to Day 5 (P < 0.05). CONCLUSIONS: Nutrient losses by CVHHD may impact adequate nutrition provision.
Michael Zappitelli; Marisa Juarez; L Castillo; Jorge Coss-Bu; Stuart L Goldstein
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-29
Journal Detail:
Title:  Intensive care medicine     Volume:  35     ISSN:  1432-1238     ISO Abbreviation:  Intensive Care Med     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-18     Completed Date:  2009-07-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  698-706     Citation Subset:  IM    
Renal Section, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
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MeSH Terms
Amino Acids / metabolism*
Child, Preschool
Critical Illness*
Energy Intake
Folic Acid / metabolism*
Infant, Newborn
Intensive Care Units, Pediatric
Kidney Failure / therapy*
Metabolic Clearance Rate / physiology*
Metals / metabolism*
Nutritional Status
Prospective Studies
Renal Dialysis / methods
Renal Replacement Therapy / methods*
Trace Elements / metabolism*
Young Adult
Reg. No./Substance:
0/Amino Acids; 0/Metals; 0/Trace Elements; 0/Vitamins; 59-30-3/Folic Acid

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