Document Detail

Continuous pump-driven hemofiltration associated with a decline in alpha-atrial natriuretic peptide.
MedLine Citation:
PMID:  2946555     Owner:  NLM     Status:  MEDLINE    
The levels of alpha-atrial natriuretic peptide (ANP) in the right atrium, pulmonary artery, radial artery, and superior vena cava plasma were measured by radioimmunoassay in eight patients with volume-expansion due to different diseases. The alpha-ANP levels were significantly increased, but became decreased after fluid removal by continuous veno-venous hemofiltration. When all alpha-ANP concentrations of different anatomical locations and hemodynamic variables were grouped, pulmonary capillary wedge pressure correlated significantly with all alpha-ANP groups, whereas right atrial mean pressure correlated with alpha-ANP levels in pulmonary artery plasma only. Alpha-ANP concentrations were distinctly lower in superior vena cava plasma than in plasma from the right atrium, pulmonary artery, and radial artery. Since alpha-ANP plays an important role in the homeostasis of sodium and fluid balance, measurement of alpha-ANP concentrations, particularly in right atrium, pulmonary artery, or radial artery plasma, might provide valuable information on the status of the critically ill.
R Pacher; M Frass; E Hartter; W Woloszczuk; C Leithner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Critical care medicine     Volume:  14     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1986 Dec 
Date Detail:
Created Date:  1987-01-06     Completed Date:  1987-01-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1010-4     Citation Subset:  AIM; IM    
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MeSH Terms
Atrial Natriuretic Factor / blood*
Critical Care*
Middle Aged
Reg. No./Substance:
85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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