Document Detail


Continuous positive-pressure ventilation decreases right and left ventricular end-diastolic volumes in the dog.
MedLine Citation:
PMID:  6985574     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated the mechanism(s) responsible for the decreased cardiac output during continuous positive-pressure ventilation (CPPV). Seven dogs were anesthetized with chloralose-urethane, intubated, and ventilated using a volume ventilator. We measured heart rate, stroke volume, and the determinants of stroke volume: left and right ventricular end-diastolic volumes, isovolumic and ejection phase indices of myocardial contractility, and pulmonary and systemic arterial pressures. Myocardial blood flow was estimated using radioactive microspheres. Variables were measured during a control period of intermittent positive-pressure ventilation (IPPV), 8-20 minutes after the initiation of CPPV using 12 cm H2O positive end-expiratory pressure (PEEP), and 8-20 minutes after the removal of PEEP. CPPV decreased cardiac output but did not affect total or regional myocardial blood flow or the ratio of subendocardial to subepicardial blood flow. Isovolumic and ejection phase indices of myocardial cointractility, heart rate, and systemic arterial pressure did not change during CPPV. Right and left ventricular end-diastolic and end-systolic volumes decreased markedly during CPPV. We conclude that CPPV decreases cardiac output in accordance with Starling's law by decreasing preload.
Authors:
J E Fewell; D R Abendschein; C J Carlson; J F Murray; E Rapaport
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation research     Volume:  46     ISSN:  0009-7330     ISO Abbreviation:  Circ. Res.     Publication Date:  1980 Jan 
Date Detail:
Created Date:  1980-02-15     Completed Date:  1980-02-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  125-32     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta, Thoracic / physiology
Blood Pressure
Cardiac Output*
Coronary Circulation
Diastole*
Dogs
Hemodynamics
Myocardial Contraction*
Positive-Pressure Respiration*
Pulmonary Circulation
Stroke Volume*
Time Factors
Ventricular Function

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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