Document Detail


Continuous perfusion with interleukin 6 (IL-6) enhances production of hematopoietic stem cells (CFU-S).
MedLine Citation:
PMID:  2784679     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The in vivo effect of human recombinant IL-6 on hematopoietic stem cells (colony forming units in spleen, CFU-S) was investigated. Normal mice perfused with IL-6 for 7 days showed an increase in the serum level of IL-6 in a dose-dependent manner. This increase was accompanied by a dramatic enhancement (approximately 8-fold) in the number of spleen CFU-S 7 days after starting perfusion, although heat-treated IL-6 did not exhibit any activities. Enhanced CFU-S number returned to normal at 13 days after cessation of perfusion. These results suggest that IL-6 could be valuable for treating various forms of hematopoietic depletion.
Authors:
C Suzuki; A Okano; F Takatsuki; Y Miyasaka; T Hirano; T Kishimoto; D Ejima; Y Akiyama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  159     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-05-11     Completed Date:  1989-05-11     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  933-8     Citation Subset:  IM    
Affiliation:
Central Research Laboratories, Ajinomoto Co., Inc., Kawasaki, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Hematopoietic Stem Cells / cytology*,  drug effects
Interleukin-6
Interleukins / blood,  pharmacology*
Macrophages / cytology,  drug effects
Mice
Mice, Inbred C3H
Mice, Inbred DBA
Perfusion
Recombinant Proteins / pharmacology
Reference Values
Chemical
Reg. No./Substance:
0/Interleukin-6; 0/Interleukins; 0/Recombinant Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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