Continuous oxygen use in nonhypoxemic emphysema patients identifies a high-risk subset of patients: retrospective analysis of the National Emphysema Treatment Trial.

Continuous oxygen use in nonhypoxemic emphysema patients identifies a high-risk subset of patients: retrospective analysis of the National Emphysema Treatment Trial.

MedLine Citation:	PMID: 18641094 Owner: NLM Status: MEDLINE
Abstract/OtherAbstract:	BACKGROUND: Continuous oxygen therapy is not recommended for emphysema patients who are not hypoxemic at rest, although it is often prescribed. Little is known regarding the clinical characteristics and survival of nonhypoxemic emphysema patients using continuous oxygen. Analysis of data from the National Emphysema Treatment Trial (NETT) offers insight into this population. METHODS: We analyzed demographic and clinical characteristics of 1,215 participants of NETT, stratifying by resting PaO(2) and reported oxygen use. Eight-year survival was evaluated in individuals randomized to medical therapy. RESULTS: At enrollment, 33.8% (n = 260) of participants nonhypoxemic at rest reported continuous oxygen use. When compared to nonhypoxemic individuals not using oxygen (n = 226), those using continuous oxygen had worse dyspnea, lower quality of life, more frequent exercise desaturation, and higher case-fatality rate. After adjusting for age, body mass index, and FEV(1) percentage of predicted, the presence of exercise desaturation accounted for the differential mortality seen between these groups. CONCLUSIONS: In the NETT, the use of continuous oxygen in resting nonhypoxemic emphysema patients was associated with worse disease severity and survival. The differential survival observed could nearly all be accounted for by the higher prevalence of exercise desaturation in those using continuous oxygen, suggesting that it is not a harmful effect of oxygen therapy contributing to mortality. It remains unclear whether continuous oxygen therapy improves survival in normoxic patients with exercise desaturation.

Authors:	Michael B Drummond; Amanda L Blackford; Joshua O Benditt; Barry J Make; Frank C Sciurba; Meredith C McCormack; Fernando J Martinez; Henry E Fessler; Alfred P Fishman; Robert A Wise;
Related Documents :	9331234 - The effect of hyperbaric oxygen on irradiated oral tissues: transmucosal oxygen tension... 3700334 - Kinetics of gram-negative bacterial cell elongation as measured by using the large rod ... 6112324 - Oxygen relieves breathlessness in "pink puffers". 4856794 - A study of the properties of hybrids of oxyhaemoglobin and deoxyhaemoglobin with two po... 7377954 - Pedalator assessment of occlusive arterial disease of the lower extremities. 17095924 - Effects of supplement timing and resistance exercise on skeletal muscle hypertrophy.
Publication Detail:	Type: Journal Article Date: 2008-07-18
Journal Detail:	Title: Chest Volume: 134 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 2008 Sep
Date Detail:	Created Date: 2008-09-09 Completed Date: 2008-10-02 Revised Date: 2009-04-09
Medline Journal Info:	Nlm Unique ID: 0231335 Medline TA: Chest Country: United States
Other Details:	Languages: eng Pagination: 497-506 Citation Subset: AIM; IM
Affiliation:	Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA. mdrummo3@jhmi.edu
Data Bank Information
Bank Name/Acc. No.:	ClinicalTrials.gov/NCT00000606
Export Citation:	APA/MLA Format Download EndNote Download BibTex
MeSH Terms
Descriptor/Qualifier:	Aged Dyspnea / physiopathology Exercise / physiology Exercise Test Female Forced Expiratory Volume / physiology Humans Kaplan-Meiers Estimate Male Middle Aged Multivariate Analysis Oxygen / therapeutic use* Oxygen Inhalation Therapy / methods* Pulmonary Emphysema / mortality, physiopathology, therapy Quality of Life Randomized Controlled Trials as Topic Rest / physiology Retrospective Studies Risk Factors Severity of Illness Index
Chemical
Reg. No./Substance:	7782-44-7/Oxygen
Investigator
Investigator/Affiliation:	Alfred P Fishman / ; Betsy Ann Bozzarello / ; Ameena Al-Amin / ; Marcia Katz / ; Carolyn Wheeler / ; Elaine Baker / ; Peter Barnard / ; Phil Cagle / ; James Carter / ; Sophia Chatziioannou / ; Karla Conejo-Gonsales / ; Kimberly Dubose / ; John Haddad / ; David Hicks / ; Neal Kleiman / ; Mary Milburn-Barnes / ; Chinh Nguyen / ; Michael Reardon / ; Joseph Reeves-Viets / ; Steven Sax / ; Amir Sharafkhaneh / ; Owen Wilson / ; Christine Young / ; Rafael Espada / ; Rose Butanda / ; Minnie Ellisor / ; Pamela Fox / ; Katherine Hale / ; Everett Hood / ; Amy Jahn / ; Satish Jhingran / ; Karen King / ; Charles Miller / ; Imran Nizami / ; Todd Officer / ; Jeannie Ricketts / ; Joe Rodarte / ; Robert Teague / ; Kedren Williams / ; John Reilly / ; David Sugarbaker / ; Carol Fanning / ; Simon Body / ; Sabine Duffy / ; Vladmir Formanek / ; Anne Fuhlbrigge / ; Philip Hartigan / ; Sarah Hooper / ; Andretta Hunsaker / ; Francine Jacobson / ; Marilyn Moy / ; Susan Peterson / ; Roger Russell / ; Diane Saunders / ; Scott Swanson / ; Rob McKenna / ; Zab Mohsenifar / ; Carol Geaga / ; Manmohan Biring / ; Susan Clark / ; Jennifer Cutler / ; Robert Frantz / ; Peter Julien / ; Michael Lewis / ; Jennifer Minkoff-Rau / ; Valentina Yegyan / ; Milton Joyner / ; Malcolm DeCamp / ; James Stoller / ; Yvonne Meli / ; John Apostolakis / ; Darryl Atwell / ; Jeffrey Chapman / ; Pierre DeVilliers / ; Raed Dweik / ; Erik Kraenzler / ; Rosemary Lann / ; Nancy Kurokawa / ; Scott Marlow / ; Kevin McCarthy / ; Pricilla McCreight / ; Atul Mehta / ; Moulay Meziane / ; Omar Minai / ; Mindi Steiger / ; Kenneth White / ; Janet Maurer / ; Terri Durr / ; Charles Hearn / ; Susan Lubell / ; Peter O'Donovan / ; Robert Schilz / ; Mark Ginsburg / ; Byron Thomashow / ; Patricia Jellen / ; John Austin / ; Matthew Bartels / ; Yahya Berkmen / ; Patricia Berkoski / ; Frances Brogan / ; Amy Chong / ; Glenda DeMercado / ; Angela DiMango / ; Sandy Do / ; Bessie Kachulis / ; Arfa Khan / ; Berend Mets / ; Mitchell O'Shea / ; Gregory Pearson / ; Leonard Rossoff / ; Steven Scharf / ; Maria Shiau / ; Paul Simonelli / ; Kim Stavrolakes / ; Donna Tsang / ; Denise Vilotijevic / ; Chun Yip / ; Mike Mantinaos / ; Kerri McKeon / ; Jacqueline Pfeffer / ; Neil MacIntyre / ; R Duane David / ; John Howe / ; R Edward Coleman / ; Rebecca Crouch / ; Dora Greene / ; Katherine Grichnik / ; David Harpole / ; Abby Krichman / ; Brian Lawlor / ; Holman McAdams / ; John Plankeel / ; Susan Rinaldo-Gallo / ; Sheila Shearer / ; Jeanne Smith / ; Mark Stafford-Smith / ; Victor Tapson / ; Mark Steele / ; Jennifer Norten / ; James Utz / ; Claude Deschamps / ; Kathy Mieras / ; Martin Abel / ; Mark Allen / ; Deb Andrist / ; Gregory Aughenbaugh / ; Sharon Bendel / ; Eric Edell / ; Marlene Edgar / ; Bonnie Edwards / ; Beth Elliot / ; James Garrett / ; Delmar Gillespie / ; Judd Gurney / ; Boleyn Hammel / ; Karen Hanson / ; Lori Hanson / ; Gordon Harms / ; June Hart / ; Thomas Hartman / ; Robert Hyatt / ; Eric Jensen / ; Nicole Jenson / ; Sanjay Kalra / ; Philip Karsell / ; Jennifer Lamb / ; David Midthun / ; Carl Mottram / ; Stephen Swensen / ; Anne-Marie Sykes / ; Karen Taylor / ; Norman Torres / ; Rolf Hubmayr / ; Daniel Miller / ; Sara Bartling / ; Kris Bradt / ; Barry Make / ; Marvin Pomerantz / ; Mary Gilmartin / ; Joyce Canterbury / ; Martin Carlos / ; Phyllis Dibbern / ; Enrique Fernandez / ; Lisa Geyman / ; Connie Hudson / ; David Lynch / ; John Newell / ; Robert Quaife / ; Jennifer Propst / ; Cynthia Raymond / ; Jane Whalen-Price / ; Kathy Winner / ; Martin Zamora / ; Reuben Cherniack / ; Philip Diaz / ; Patrick Ross / ; Tina Bees / ; Jan Drake / ; Charles Emery / ; Mark Gerhardt / ; Mark King / ; David Rittinger / ; Mahasti Rittinger / ; Keith Naunheim / ; Robert Gerber / ; Joan Osterloh / ; Susan Borosh / ; Willard Chamberlain / ; Sally Frese / ; Alan Hibbit / ; Mary Ellen Kleinhenz / ; Gregg Ruppel / ; Cary Stolar / ; Janice Willey / ; Francisco Alvarez / ; Cesar Keller / ; Gerard Criner / ; Satoshi Furukawa / ; Anne Marie Kuzma / ; Roger Barnette / ; Neil Brister / ; Kevin Carney / ; Wissam Chatila / ; Frances Cordova / ; Gilbert D'Alonzo / ; Michael Keresztury / ; Karen Kirsch / ; Chul Kwak / ; Kathy Lautensack / ; Madelina Lorenzon / ; Ubaldo Martin / ; Peter Rising / ; Scott Schartel / ; John Travaline / ; Gwendolyn Vance / ; Philip Boiselle / ; Gerald O'Brien / ; Andrew Ries / ; Robert Kaplan / ; Catherine Ramirez / ; David Frankville / ; Paul Friedman / ; James Harrell / ; Jeffery Johnson / ; David Kapelanski / ; David Kupferberg / ; Catherine Larsen / ; Trina Limberg / ; Michael Magliocca / ; Frank J Papatheofanis / ; Dawn Sassi-Dambron / ; Melissa Weeks / ; Mark Krasna / ; Henry Fessler / ; Iris Moskowitz / ; Timothy Gilbert / ; Jonathan Orens / ; Steven Scharf / ; David Shade / ; Stanley Siegelman / ; Kenneth Silver / ; Clarence Weir / ; Charles White / ; Fernando Martinez / ; Mark Iannettoni / ; Catherine Meldrum / ; William Bria / ; Kelly Campbell / ; Paul Christensen / ; Kevin Flaherty / ; Steven Gay / ; Paramjit Gill / ; Paul Kazanjian / ; Ella Kazerooni / ; Vivian Knieper / ; Tammy Ojo / ; Lewis Poole / ; Leslie Quint / ; Paul Rysso / ; Thomas Sisson / ; Mercedes True / ; Brian Woodcock / ; Lori Zaremba / ; Larry Kaiser / ; John Hansen-Flaschen / ; Mary Louise Dempsey / ; Abass Alavi / ; Theresa Alcorn / ; Selim Arcasoy / ; Judith Aronchick / ; Stanley Aukberg / ; Bryan Benedict / ; Susan Craemer / ; Ron Daniele / ; Jeffrey Edelman / ; Warren Gefter / ; Laura Kotler-Klein / ; Robert Kotloff / ; David Lipson / ; Wallace Miller / ; Richard O'Connell / ; Staci Opelman / ; Harold Palevsky / ; William Russell / ; Heather Sheaffer / ; Rodney Simcox / ; Susanne Snedeker / ; Jennifer Stone-Wynne / ; Gregory Tino / ; Peter Wahl / ; James Walter / ; Patricia Ward / ; David Zisman / ; James Mendez / ; Angela Wurster / ; Frank Sciurba / ; James Luketich / ; Colleen Witt / ; Gerald Ayres / ; Michael Donahoe / ; Carl Fuhrman / ; Robert Hoffman / ; Joan Lacomis / ; Joan Sexton / ; William Slivka / ; Diane Strollo / ; Erin Sullivan / ; Tomeka Simon / ; Catherine Wrona / ; Gerene Bauldoff / ; Manuel Brown / ; Elisabeth George / ; Robert Keenan / ; Theodore Kopp / ; Laurie Silfies / ; Joshua Benditt / ; Douglas Wood / ; Margaret Snyder / ; Kymberley Anable / ; Nancy Battaglia / ; Louie Boitano / ; Andrew Bowdle / ; Leighton Chan / ; Cindy Chwalik / ; Bruce Culver / ; Thurman Gillespy / ; David Godwin / ; Jeanne Hoffman / ; Audra Ibrahim / ; Diane Lockhart / ; Stephen Marglin / ; Kenneth Martay / ; Patricia McDowell / ; Donald Oxorn / ; Liz Roessler / ; Michelle Toshima / ; Susan Golden / ; Lynn Bosco / ; Yen-Pin Chiang / ; Carolyn Clancy / ; Harry Handelsman / ; Steven M Berkowitz / ; Tanisha Carino / ; Joe Chin / ; JoAnna Baldwin / ; Karen McVearry / ; Anthony Norris / ; Sarah Shirey / ; Claudette Sikora / ; Steven Sheingold / ; Steven Piantadosi / ; James Tonascia / ; Patricia Belt / ; Amanda Blackford / ; Karen Collins / ; Betty Collison / ; Ryan Colvin / ; John Dodge / ; Michele Donithan / ; Vera Edmonds / ; Gregory L Foster / ; Julie Fuller / ; Judith Harle / ; Rosetta Jackson / ; Shing Lee / ; Charlene Levine / ; Hope Livingston / ; Jill Meinert / ; Jennifer Meyers / ; Deborah Nowakowski / ; Kapreena Owens / ; Shangqian Qi / ; Michael Smith / ; Brett Simon / ; Paul Smith / ; Alice Sternberg / ; Mark Van Natta / ; Laura Wilson / ; Robert Wise / ; Robert M Kaplan / ; J Sanford Schwartz / ; Yen-Pin Chiang / ; Marianne C Fahs / ; A Mark Fendrick / ; Alan J Moskowitz / ; Deb Pathak / ; Scott Ramsey / ; Steven Sheingold / ; A Laurie Shroyer / ; Judith Wagner / ; Roger Yusen / ; Scott Ramsey / ; Ruth Etzioni / ; Sean Sullivan / ; Douglas Wood / ; Thomas Schroeder / ; Karma Kreizenbeck / ; Kristin Berry / ; Nadia Howlader / ; Eric Hoffman / ; Janice Cook-Granroth / ; Angela Delsing / ; Junfeng Guo / ; Geoffrey McLennan / ; Brian Mullan / ; Chris Piker / ; Joseph Reinhardt / ; Blake Robinswood / ; Jered Sieren / ; William Stanford / ; John A Waldhausen / ; Gordon Bernard / ; David DeMets / ; Mark Ferguson / ; Eddie Hoover / ; Robert Levine / ; Donald Mahler / ; A John McSweeny / ; Jeanine Wiener-Kronish / ; O Dale Williams / ; Magdy Younes / ; Gerard Criner / ; Charles Soltoff / ; Gail Weinmann / ; Joanne Deshler / ; Dean Follmann / ; James Kiley / ; Margaret Wu /
Comments/Corrections
Comment In:	Chest. 2009 Mar;135(3):885-6; author reply 886 [PMID: 19265107 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document: A randomized trial of CT fluoroscopic-guided bronchoscopy vs conventional bronchoscopy in patients w...
Next Document: Prevention of venous thromboembolism in neurosurgery: a metaanalysis.